Biolegend, 377106, Purified anti-human HVCN1 Antibody, 100μg

HVCN1 (hydrogen voltage-gated channel 1), is a voltage gated proton-selective channel. HVCN1 is expressed in immune cells, spermatozoa, and upper respiratory tract epithelial cells. HVCN1 mediates the proton conductance required to maintain inhibition of membrane depolarization and acidification of cytoplasm. HVCN1 is required by phagocytes for oxidative burst that underlies microbial killing and in B cells to facilitates antibody production. HVCN1 can also regulate functions in other cells including spermatozoa.
100μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Recombinant human HVCN1
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: ICFC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
Structure: Transmembrane protein with four helix transmembrane domain and a coiled coil c-terminal cytoplasmic domain
Distribution: Immune cells (B-cells, Neutrophils, Monocytes), spermatozoa, upper respiratory epithelium
Function: Proton transporter
Molecular Family: Ion Channels
Antigen References: Zhu X, et al. 2013. BMC Immunol. 14:24. Hondares E, et al. 2014. Proc. Natl. Acad. Sci. 111:50. Okochi Y, et al. 2021. Int. J. Mol. Sci. 22:2620. Wang Y, et al. 2011. Biochem. Biophys. Res. Commun. 2: 412. Cherny VV, et al. 2015. J. Gen. Physiol. 5: 146. De Coursey TE. 2015. Biochemistry. 54: 21.
Gene ID: 84329
UniProt: View information about HVCN1 on UniProt.org
Clone: W23068A
Regulatory Status: RUO
Other Names: HVCN1 (hydrogen voltage gated channel 1), HV1, VSOP (voltage sensor domain-only protein)
Isotype: Rat IgG2a, κ