Biolegend, 383902, Purified anti-human EphA1 Antibody, 100μg

Ephrin type-A receptor 1 (hEpha1), also known as EPH tyrosine kinase belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. The protein consists of 976 a.a. with a molecular weight of 108 kD. The Eph subfamily represents the largest group of receptor protein tyrosine kinases and is divided into two major subclasses: ephrin-A and ephrin-B. They have been implicated in various developmental processes, including axonal guidance, angiogenesis, morphogenesis and carcinogenesis and widely expressed in differentiated epithelial cells in the bone marrow, spleen, thymus, and testis.
100μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Rat
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2927851 (BioLegend Cat. No. 383902)
Structure: The protein consists of 976 a.a. with a molecular weight of 108 kD.
Distribution: Cytoplasmic and membranous expression in most tissues, including parathyroid gland
Function: Kinase, receptor, transferase, tyrosine-protein kinase. EphA1/A2 and ephrin‐A1 are over‐expressed or downregulated in various types of cancer.
Interaction: EphA1/A2 and ephrin‐A1 are correlated with tumor malignancy and prognosis.
Ligand/Receptor: Ephrin-A1
Cell Type: B cells, Endothelial cells, Epithelial cells, T cells, Thymocytes
Biology Area: Cancer Biomarkers, Cell Adhesion, Immunology
Molecular Family: Protein Kinases/Phosphatase
Antigen References: Katsuaki L and Yoshiro M. 2019. Cancer Sci. 110:841. Holen L, et al. 2010. J Leukoc Biol. 87:1059-68.
Gene ID: 2041
UniProt: View information about EphA1 on UniProt.org
Clone: A20047D
Regulatory Status: RUO
Other Names: EPH Receptor A1, Erythropoietin-Producing Hepatoma Receptor, Tyrosine-Protein Kinase Receptor EPH, Ephrin Type-A Receptor 1, EC 2.7.10.1, HEpha1, EPHT1, EPHT, EPH, Erythropoietin-Producing Hepatoma Amplified Sequence
Isotype: Rat IgG2a, κ