Biolegend, 384502, Purified anti-human Bcl11b Antibody, 100μg

The transcription factor, Bcl11b, is expressed in the thymus, mainly T cells. It is indispensable for T lineage development. When Bcl11b was deleted, T cells from all developmental stages acquired NK cell properties and concomitantly lost or decreased T cell-associated gene expression. These induced T-to-natural killer (ITNK) cells, which were morphologically and genetically similar to conventional NK cells, killed tumor cells in vitro , and effectively prevented tumor metastasis in vivo . Therefore, ITNKs may represent a new cell source for cell-based therapies.
100μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: RP 1-250 (generated by E. coli)
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: ICFC - Quality testedWB, IHC-P - Verified
Recommended Usage: Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2941561 (BioLegend Cat. No. 384502)
Structure: 894 amino acids with molecular weight of 96 kD. It encodes a C2H2-type zinc finger protein and is closely related to BCL11A.
Distribution: Nucleus
Function: Tumor-suppressor protein involved in T-cell lymphomas. A key regulator of both differentiation and survival during thymocyte development.
Interaction: Interacts with TFCOUP1, SIRT1, ARP1, and EAR2
Antigen References: Liu P, et al. 2011. Immunol Rev. 238:138-49. Ikawa T, et al. 2010. Science. 329:93-6. Li L, et al. 2010. Science. 329:89-93. Li P, et al. 2010. Science. 329:85-9. Tydell CC, et al. 2007. J Immunol. 179:4238. Avram D, et al. 2002. Biochem J. 368:555-63.
Gene ID: 19882
UniProt: View information about Bcl11b on UniProt.org
Clone: W17189A
Regulatory Status: RUO
Other Names: CTIP-2, CTIP2, hRIT1-alpha, SMARCM2
Isotype: Rat IgG2a, κ