Biolegend, 387005, APC anti-human CD213a2 (IL13Rα2) Antibody, 25tests

CD213a2, also known as IL13Rα2, is a type I transmembrane protein and member of the hematopoietin family. IL13Rα2 is the high affinity receptor for IL-13, but it possibly acts as a decoy receptor to antagonize IL-13Rα1/IL-4Ra-mediated IL-13 biological functions. IL13Rα2 is expressed by fibroblasts, smooth muscle cells, keratinocytes and activated B cells. However, its presence on the cell surface is highly regulated. CD213a2 is also expressed in various types of cancer which makes it an attractive therapeutic target.
25tests
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Recombinant human IL13Rα2, Cys22-Leu342
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Excitation Laser: Red Laser (633 nm)
RRID: AB_2936651 (BioLegend Cat. No. 387005) AB_2936651 (BioLegend Cat. No. 387006)
Structure: Member of the hematopoietin family, type I transmembrane protein, contains 1 fibronectin type III domain
Distribution: Fibroblasts, smooth muscle cells, keratinocytes, activated B cells
Function: Possible decoy receptor, antagonist of CD213a1, internalization of IL-13
Ligand/Receptor: IL-13
Cell Type: B cells, Fibroblasts
Biology Area: Cell Biology, Immunology, Transcription Factors
Molecular Family: CD Molecules, Cytokine/Chemokine Receptors
Antigen References: Mitchell J, et al. 2010. Curr Opin Investig Drugs. 11:527-34. Strober W, et al. 2009. Curr Mol Med. 9:740-50. Tabata Y, et al. 2007. Curr Allergy Asthma Rep. 7:338-45.
Gene ID: 3598
UniProt: View information about CD213a2 on UniProt.org
Clone: A21071B
Regulatory Status: RUO
Other Names: CD213a2, IL-13RA2, IL-13R, IL13BP, CT19
Isotype: Mouse IgG2b, κ