Biolegend, 390704, Purified anti-human CD262 (DR5, TRAIL-R2) Antibody, 100μg

DR5, also known as TRAIL-R2, TRICK2, KILLER, and CD262, is 55 kD member 10B of the TNF receptor superfamily (TNFRSF10B). It binds the cytotoxic ligand, TRAIL, and induces apoptosis. The DR5 receptor is broadly expressed on a variety of normal tissues and many tumors. DR5 expression has been reported to be upregulated in human cells by interferon-α, 2-methoxyestradiol, and paclitaxel, and downregulated by adenoviral E3 proteins.
100μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Recombinant Human TNFRSF10B
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality testedICC - Verified
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. For immunocytochemistry, a concentration of 5.0 μg/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: Clone A21121I does not block the staining of reference clone DJR2-4 (7-8)Recombinant protein completely blocks the staining of test clone A21121I.
RRID: AB_3662368 (BioLegend Cat. No. 390704)
Structure: TNFR superfamily, 55 kD
Distribution: Broadly expressed on normal and tumor cells
Function: Induces apoptosis
Ligand/Receptor: TRAIL
Biology Area: Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology
Molecular Family: CD Molecules, Cytokine/Chemokine Receptors
Antigen References: MacFarlane M, et al. 1997. J Biol Chem. 272:25417-20. Walczak H, et al. 1997. EMBO J. 16:5386-97. Shigeno M, et al. 2003. Oncogene. 22:1653-62. LaVallee TM, et al. 2003. Cancer Res. 63:468-75. Nimmanapalli R, et al. 2001. Cancer Res. 61:759-63.
Gene ID: 8795
UniProt: View information about CD262 on UniProt.org
Clone: A21121I
Regulatory Status: RUO
Other Names: TRAIL-R2, KILLER, TRICK2, TNFRSF10B, Ly98, CD262
Isotype: Mouse IgG2a, κ