Biolegend, 391406, APC anti-human CXCR7 Antibody, 100tests

CXCR7, also known as RDC1, belongs to a subgroup of C-X-C chemokine receptors, which are part of a large protein family of G protein-coupled receptors (GPCR). CXCR7 binds with a high-affinity to CXCL12/SDF-1 and CXCL11/I-TAC, which regulates the trafficking and activation of leukocytes. It is also a co-receptor for the entry of HIV-1. The binding of a ligand to CXCR7 induces proliferation and migration of immature neurons, glia, and their precursors. CXCR7 expression occurs on a wide variety of tissues and cells including monocytes, B cells, T cells, and mature dendritic cells. Surface expression of CXCR7 has been also reported in tumor cells, activated endothelial cells, and fetal liver cells.
100tests
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Excitation Laser: Red Laser (633 nm)
Product Citations: Zhang X, et al. 2021. Oncogene. 40:1516. PubMed
RRID: AB_2565682 (BioLegend Cat. No. 391405) AB_2565683 (BioLegend Cat. No. 391406)
Structure: G Protein-Coupled Receptor super family
Distribution: Monocytes, B cells, T cells, and mature dendritic cells.
Function: Regulates trafficking and activation of leukocytes.
Ligand/Receptor: CXCL12/SDF-1 and CXCL11/I-TAC.
Cell Type: B cells, Dendritic cells, Monocytes, T cells
Biology Area: Cell Biology, Immunology, Signal Transduction
Molecular Family: CD Molecules, Cytokine/Chemokine Receptors, GPCR
Antigen References: 1. Torossian F, et al. 2014. Blood 123:191. 2. Walentowicz-Sadlecka M, et al. 2014. PLoS One 1:e84629. 3. Yates TJ, et al. 2013. Cancer 119:61. 4. Burns JM, et al. 2006. J. Exp. Med. 203:2201. 5. Infantino S, et al. 2006. J. Immunol. 176:2197.
Gene ID: 57007
UniProt: View information about CXCR7 on UniProt.org
Clone: 10D1-J16
Regulatory Status: RUO
Other Names: Chemokine (C-X-C motif) receptor 7, RDC1, CMKOR1, GPR159, ACKR3
Isotype: Mouse IgG2a, κ