Biolegend, 391609, APC anti-human FPR1 Antibody, 25tests

FPR1 (Formyl Peptide Receptor 1), a G protein-coupled receptor consisting of seven transmembrane domains, is expressed on phagocytic cells and other cell types such as monocytes.  FPR1 is a high affinity receptor for N -formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors.  Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release.  Endogenous peptide ligands for this receptor have also been identified.   FPR1 mediates the response to invasion of the host by microbial pathogens and is important in host defense and inflammation.
25tests
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Full length human FPR1 transfected cells
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Excitation Laser: Red Laser (633 nm)
Product Citations: França TT, et al. 2021. JCI Insight. 6:. PubMed
RRID: AB_2721452 (BioLegend Cat. No. 391609) AB_2721453 (BioLegend Cat. No. 391610)
Structure: Seven transmembrane domains, G-protein coupled receptor (GPCR)
Distribution: Monocytes, Neutrophils
Function: Chemotaxis
Ligand/Receptor: N-formylated peptides, Ac9-25, FAM19A4, Annexin A1
Cell Type: Eosinophils, Monocytes, Neutrophils
Biology Area: Immunology, Innate Immunity
Antigen References: 1. Boulay F, et al. 1990. Biochemistry 29:11123. 2. Ye RD, et al. 2009. Pharmacol. Rev. 61:119. 3. Prossnitz ER, et al. 1999. Biochemistry 38:2240. 4. Wang W, et al. 2015. Cell Mol. Immunol. 12:615.
Gene ID: 2357
UniProt: View information about FPR1 on UniProt.org
Clone: W15086B
Regulatory Status: RUO
Other Names: fMet-Leu-Phe receptor 1, FMLP, FPR, fMLF-R
Isotype: Mouse IgG1, κ