Biolegend, 393805, PE/Dazzle™ 594 anti-human CD110 Antibody, 25tests

CD110 is a type I transmembrane glycoprotein which functions as a receptor for thrombopoietin; binding causes the proliferation and differentiation of megakaroyocytes in addition to the production of platelets and protection of stem cells from apoptosis. CD110 is primarily expressed on hematopoietic stem cells, hematopoietic precursor cells, cells of the megakaryocytic lineage, and platelets.
25tests
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Human CD110 transfectants
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation: The antibody was purified by affinity chromatography and conjugated with PE/Dazzle™ 594 under optimal conditions.
Concentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood. * PE/Dazzle™ 594 has a maximum excitation of 566 nm and a maximum emission of 610 nm.
Excitation Laser: Blue Laser (488 nm)Green Laser (532 nm)/Yellow-Green Laser (561 nm)
RRID: AB_2750420 (BioLegend Cat. No. 393805) AB_2750421 (BioLegend Cat. No. 393806)
Structure: Type I transmembrane glycoprotein
Distribution: Hematopoietic stem cells, a subfraction of hematopoietic precursor cells, cells of the megakaryocytic lineage, and platelets.
Function: Megakaryocytopoiesis and platelet formation
Interaction: THPO, ATXN2L, JAK2
Ligand/Receptor: Thrombopoietin
Biology Area: Immunology
Molecular Family: CD Molecules
Antigen References: Ninos JM, et al. 2006. J. Transl. Med. 16:4-9. Broudy VC, et al. 1996. Blood. 88:2026-32. Wang X, et al. 2016. Blood. 127:3398-409.
Gene ID: 4352
UniProt: View information about CD110 on UniProt.org
Clone: S16017A
Regulatory Status: RUO
Other Names: TPOR, c-MPL, MPLV
Isotype: Mouse IgG2b, κ