Biolegend, 395405, APC anti-human TSPAN33 (BAAM) Antibody, 25tests

TSPAN33, also known as BAAM, is a 32 kDa protein member of the TM4 superfamily (TM4SF). TSPAN33 have four transmembrane regions and two extracellular loops, one of them is a cysteine-rich long extracellular loop (LEL), characteristic of the TM4SF. TSPAN33 interacts with different molecules such as integrins and other tetraspanins. TSPAN33 is expressed by activated B cells, some B cell lymphomas, macrophages and in cells from the convoluted tubules and collecting ducts in the kidney. In macrophages TSPAN33 modulates TLR-induced proinflammatory gene expression, but its function in other cells is unknown.
25tests
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Human TSPAN33-transfected cells
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Excitation Laser: Red Laser (633 nm)
RRID: AB_2801043 (BioLegend Cat. No. 395405) AB_2801044 (BioLegend Cat. No. 395406)
Structure: Member of the TM4 superfamily, TspanC8 subgroup, 32kD, 4 transmembrane regions, 1 cysteine-rich long extracellular loop (LEL).
Distribution: Activated B cells, some B cell lymphomas, macrophages, convoluted tubules and collecting ducts from kidney
Function: Modulates TLR-induced proinflammatory gene expression
Cell Type: B cells, Macrophages
Biology Area: Cancer Biomarkers, Immuno-Oncology, Signal Transduction
Molecular Family: Adhesion Molecules
Antigen References: Pérez-Martínez CA, et al. 2017. Scand J Immunol. 86:23. Ruiz-García A, et al. 2016. J Immunol. 197:3371. Luu VP, et al. 2013. Clin Immunol. 149:388. Chen Z, et al. 2005. Cancer Genet Cytogenet. 162:95. Maecker HT et al. 1997. FASEB J. 11:428.
Gene ID: 340348
UniProt: View information about TSPAN33 on UniProt.org
Clone: SA17RN1
Regulatory Status: RUO
Other Names: Tetraspanin-33, BAAM, Penumbra, PEN
Isotype: Mouse IgG2b, κ