Biolegend, 396805, APC anti-human CD210b (IL-10RB) Antibody, 25tests

CD210b is a Type 1 transmembrane glycoprotein also known as, subunit 2 (IL-10R2) and is an essential chain for the IL-10 receptor complex. The IL-10 receptor complex is made up of alpha (IL10-RA) and beta (IL-10RB) subunits. Coexpression of these subunits has been shown to be required for IL10 induced signal transduction. Binding of dimeric IL-10 to two alpha subunits can cause the recruitment of two beta subunits resulting in the transduction of the intracellular JAK/STAT pathway.
25tests
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Human IL10RB-transfected cells
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Excitation Laser: Red Laser (633 nm)
RRID: AB_2892467 (BioLegend Cat. No. 396805) AB_2892467 (BioLegend Cat. No. 396806)
Structure: Type 1 transmembrane glycoprotein belonging to the cytokine receptor family.
Distribution: CD210b is expressed by a variety of cell types including T cells, B cells, NK cells, monocytes and macrophages.
Function: Activates STAT1, STAT3, Jak1, Tyk and is a component of cytokine receptor complexes specific for IL-22, IL-26, IL-28, and IL-29.
Ligand/Receptor: IL-10
Cell Type: B cells, Macrophages, NK cells, T cells, Thymocytes
Biology Area: Adaptive Immunity, Immunology, Signal Transduction
Molecular Family: Cytokine/Chemokine Receptors
Antigen References: Donnelly RP, et al. 2004. J Leukoc Biol. 76(2):314-321. Koppelman B, et al. 1997. Immunity. (6): 861-871 Kotenko SV, et al. 1997. EMBO J. 16(19):5894-5903. Liu Y, et al. 1995. J Immunol. 152(4):1821-1829.
Gene ID: 3588
UniProt: View information about CD210b on UniProt.org
Clone: S17009F
Regulatory Status: RUO
Other Names: Interleukin 10 receptor subunit beta, CRFB4, CRF2-4, D21S58, D21S66, CDW210B
Isotype: Mouse IgG2a, κ