Biolegend, 399805, PE/Cyanine7 anti-human CD200 (OX2) Antibody, 25tests

CD200, also known as OX2, is a member of the immunoglobulin superfamily (IgSF). It is a monomorphic cell surface glycoprotein that is expressed on thymocytes, neurons, endothelium, follicular dendritic cells in all lymphoid organs, a subset of CD34+ progenitor cells, and at low levels on some smooth muscle and B lymphocytes. It is not expressed on NK cells, monocytes, granulocytes, or platelets. CD200 costimulates T cell proliferation. It may regulate myeloid cell activity in a variety of tissues. The interaction between CD200 (OX2) and CD200 receptor (OX2R) system is of importance in the control of macrophage and granulocyte activation, which may contribute to pathways that suppress and limit macrophage induced inflammatory damage in tissue.
25tests
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Recombinant human CD200
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation: The antibody was purified by affinity chromatography and conjugated with PE/Cyanine7 under optimal conditions.
Concentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Excitation Laser: Blue Laser (488 nm)Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes: Clone A18042B antibody is able to completely block the staining of OX-104 antibody, but OX-104 antibody does not completely block the staining of A18042B antibody.
RRID: AB_2876727 (BioLegend Cat. No. 399805) AB_2876727 (BioLegend Cat. No. 399806)
Structure: Ig superfamily, 80 kD
Distribution: T cells, neurons, endothelium
Function: Costimulates T cell proliferation
Ligand/Receptor: CD200R
Cell Type: Endothelial cells, Neurons, T cells
Biology Area: Cell Biology, Costimulatory Molecules, Immunology, Neuroscience, Neuroscience Cell Markers
Molecular Family: CD Molecules
Antigen References: Wright GJ, et al. 2001. Immunology. 102:173. Foster-Cuevas M, et al. 2004. J. Virol. 78:7667. Mason D, et al. 2002. ed. Leukocyte Typing VII. New York:Oxford Univ. Press. Broderick C, et al. 2002. Am. J. Pathol. 161:1669.
Gene ID: 4345
UniProt: View information about CD200 on UniProt.org
Clone: A18042B
Regulatory Status: RUO
Other Names: OX-2, OX2
Isotype: Mouse IgG1, κ