Biolegend, 433204, ELISA MAX™ Deluxe Set Human CXCL13 (BLC), 5plates

CXCL13, also known as B-Lymphocyte Chemoattractant (BLC) or B Cell-Attracting chemokine 1 (BCA-1), is a small cytokine belonging to the CXC chemokine family. As a strong chemoattractant for B cells, it is highly expressed in the follicles of Peyer’s patches, spleen, and lymph nodes. It is also expressed by T follicular helper cells, dendritic cells, and stromal cells (including marginal reticular cells (MRCs) and follicular dendritic cells (FDCs)) in B cell areas of secondary lymphoid tissue. CXCL13 and its receptor CXCR5 regulate compartmentalization of B cells and T cells in secondary lymphoid organs. During the migration in the follicle, B cells are in contact with FDCs, MRCs, and cells localized around the follicle perimeter, such as sinus-associated macrophages and T cell zone associated DCs. Subsequent to the migration through the FDC network, B cells travel through the T cell zone-proximal follicle. In this migration, CCL21, CCL19, CCR7 and CXCR5 are involved. CXCL13, CCL19, and CCL21 take part in the formation of tertiary lymphoid tissues in chronic antigen-induced arthritis. In CXCL13-deficient mice, B cells fail to organize in polarized follicular clusters and instead appeare as a ring of cells at the perimeter of T-cell areas. CXCL13 is highly expressed at sites of new lymphoid tissue formation in a variety of chronic inflammatory conditions. High expression of CXCL13 has been linked to lupus, Helicobacter pylori-associated gastritis, multiple sclerosis, rheumatoid arthritis, and the allergic airway inflammatory process.
5plates
Verified Reactivity: Human
Application: ELISA
Sensitivity: 2.5 + 0.94 pg/mL
Standard Range: 9.4 - 600 pg/mL
Cell Type: B cells, Endothelial cells, Monocytes
Biology Area: Cancer Biomarkers, Cell Biology, Immuno-Oncology, Immunology
Molecular Family: Cytokines/Chemokines
Gene ID: 10563
UniProt: View information about CXCL13 on UniProt.org
Regulatory Status: RUO
Other Names: Human BLC
Q: Do the ELISA MAX™ Deluxe Sets come with plates?
A: No, ELISA MAX™ Deluxe Sets do not come with plates. Coating Buffer and Assay Diluent (for blocking and dilutions) are included in these sets. Plates can be ordered separately (Cat No. 423501), and instructions for coating the plates are in the sets’ product manuals.