Biolegend, 433916, ELISA MAX™ Deluxe Set Human IL-17A, 20plates

&Please contact our sales representative for bulk pricing quotations. IL-17 or IL-17A originally identified as cytotoxic T lymphocyte-associated antigen-8 (CTLA-8) in mouse, is a founding member of the IL-17 family of cytokines. IL-17A is mainly produced by a small subset of T helper cells called Th17 cells. IL-17A is a 155 amino acid protein that is a disulfide linked, homodimeric, secreted glycoprotein with a molecular mass of 35 kD. The amino acid sequence of human IL-17A is 63% and 58% identical to mouse and rat IL-17A, respectively, and 72% identical to the ORF13 of Herpesvirus saimiri. IL-17A exhibits multiple biological activities including the induction of various proinflammatory cytokines and chemokines such as IL-6, IL-8, G-CSF, GM-CSF, GRO-α, and MCP-1 on a variety of cell types. IL-17A is also involved in the activation of NF-kB and costimulation of T cell proliferation. As a result of these roles, IL-17A has been linked to many immune/autoimmune related diseases including rheumatoid arthritis, asthma, lupus, and multiple sclerosis. ELISA MAX™ Set Deluxe is specifically engineered for accurate recovery and measurement of analytes in complex fluids, such as serum and plasma (as well as activated cell cultures) without any interference by confounding serum factors, such as heterophilic antibody or rheumatoid factor.
20plates
Verified Reactivity: Human
Application: ELISA
Product Citations: Fahrner JE, et al. 2022. Cancer Discov. 12:958. PubMed Kan J, et al. 2016. Allergol Int. 65 Suppl: S11-6. PubMed Ho CH, et al. 2021. Arthritis Res Ther. 23:199. PubMed Wang H, et al. 2021. J Immunother Cancer. 9:. PubMed You Y, et al. 2021. Mol Med Rep. 24:. PubMed Chen ZX, et al. 2022. Adv Clin Exp Med. Online ahead of print. PubMed Lourenço JD, et al. 2021. Cells. 10:. PubMed Li YR, et al. 2021. Cell Rep Med. 2:100449. PubMed Eken A, et al. 2019. Front Immunol. 10:217. PubMed Takuathung M, et al. 2017. Evid Based Complement Alternat Med. 10.1155/2017/5906539. PubMed
Sensitivity: 2 pg/mL
Standard Range: 3.9-250 pg/mL
Cell Sources: Activated T cell subpopulation
Biology Area: Immunology, Neuroinflammation, Neuroscience
Molecular Family: Cytokines/Chemokines
Gene ID: 3605
UniProt: View information about IL-17A on UniProt.org
Regulatory Status: RUO
Other Names: IL-17A ELISA Kit, IL-17 ELISA Kit
Q: Do the ELISA MAX™ Deluxe Sets come with plates?
A: No, ELISA MAX™ Deluxe Sets do not come with plates. Coating Buffer and Assay Diluent (for blocking and dilutions) are included in these sets. Plates can be ordered separately (Cat No. 423501), and instructions for coating the plates are in the sets’ product manuals.