Biolegend, 434505, ELISA MAX™ Deluxe Set Human IL-22, 10plates

Please contact our sales representative for bulk pricing quotations. IL-22 is a cytokine structurally related to IL-10. It was originally identified in mouse as a gene induced by IL-9 in T cells and mast cells. IL-22 was initially designated as ILTIF (IL-10-related T cell-derived inducible factor). IL-22 belongs to a family of cytokines with limited homology to IL-10, namely IL-10, IL-19, IL-20, IL-24, IL-26, IL-28A, IL-28B and IL-29 (the later three also known as IFN-gamma’s). Human IL-22 shares 79% amino acid identity with mouse IL-22 and 25% identity with human IL-10. IL-22 biological activity is initiated by the binding to a cell surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein, IL-22BP, which share sequence similarity with an extracellular region of IL-22R1 (sIL-22R1). Both chains of the IL-22R complex belong to the class II CRF. Two types of IL-22 binding receptors have been discovered, a membrane-bound receptor and a soluble receptor, both encoded by different genes. IL-22 is produced by immune cells and acts on nonimmune cells to regulate local tissue inflammation. As a product of T helper 17 lineage of CD4 (+) effector lymphocytes, IL-22 plays a critical role in mucosal immunity as well as in deregulated inflammation observed in autoimmune diseases. BioLegend's ELISA Max™ Sets are Engineered for Sensitive, Precise and Reliable Serum and Plasma Cytokine Quantitation. The sets provide all the time-savings, convenience and performance of a high-end, commercial ELISA kit for a fraction of the price! BioLegend's ELISA Max™ Sets, in two appealing formats, address the need for sensitivity, accuracy, dependability, and versatility of an ELISA development system, while providing maximum cost effectiveness, value, and ease of use. Both the ELISA Max™ Set Standard and ELISA Max™ Set Deluxe are specifically engineered for accurate recovery and measurement of analytes in complex fluids, such as serum and plasma (as well as activated cell cultures) without any interference by confounding serum factors, such as heterophilic antibody or rheumatoid factor.
10plates
Verified Reactivity: Human
Application: ELISA
Product Citations: Wong LS, et al. 2020. J Invest Dermatol. 140:702. PubMed Pidasheva S, et al. 2011. PLoS One. 6:e25038. PubMed Chen ZX, et al. 2022. Adv Clin Exp Med. Online ahead of print. PubMed Eken A, et al. 2019. Front Immunol. 10:217. PubMed Ramos JS, et al. 2020. Diabetes Metab Syndr Obes. 2.238194444. PubMed Takuathung M, et al. 2017. Evid Based Complement Alternat Med. 10.1155/2017/5906539. PubMed Laursen MF, et al. 2021. Nat Microbiol. 6:1367. PubMed Torquati L, et al. 2019. Nutrients. 11:. PubMed
Sensitivity: 16 pg/ml
Standard Range: 31.3-2,000 pg/mL
Cell Sources: Thymic lymphomas, T cells, activated T cells, macrophages, and mast cells, Th17
Biology Area: Immunology, Stem Cells
Molecular Family: Cytokines/Chemokines
Gene ID: 50616
UniProt: View information about IL-22 on UniProt.org
Regulatory Status: RUO
Other Names: Human IL-22 ELISA Kit, hIL-22 ELISA Kit, hIL-22 ELISA Max kit
Q: Do the ELISA MAX™ Deluxe Sets come with plates?
A: No, ELISA MAX™ Deluxe Sets do not come with plates. Coating Buffer and Assay Diluent (for blocking and dilutions) are included in these sets. Plates can be ordered separately (Cat No. 423501), and instructions for coating the plates are in the sets’ product manuals.