Biolegend, 439905, ELISA MAX™ Deluxe Set Human CXCL10 (IP-10), 10plates

Please contact our sales representative for bulk pricing quotations. CXCL10, also known as IP-10, is a glutamic acid-leucine-arginine motif negative chemokine structurally and functionally related to MIG (CXCL9) and ITAC (CXCL11). CXCL10 is induced in a variety of cells in response to interferon-γ and lipopolysaccharide. These cell types include monocytes, macrophages, fibroblasts, and epithelial cells. CXCL10 (IP-10) chemoattracts CD4+ and CD8+ T cells, NK, and NKT cells via binding to its receptor CXCR3, which is shared with MIG and ITAC. CXCL10 inhibits neovascularization in tumors and in wound healing in vivo . It also has anti-proliferative effects on endothelial cells in vitro , and angiostatic and antitumor effects in vivo . It has been suggested that the antiproliferative effect of CXCL10 in endothelial cells is CXCR3-independent and that it is mediated through glycosaminoglycan interaction. CXCL10 also possesses antimicrobial activity against E. coli and L. monocytogenes , and both the spore and bacillus forms of B. anthracis . It has been reported that CXCL10 may be important in the pathogenesis of chronic HCV infection, and the circulating CXCL10 concentration was increased in the early and subclinical stage of Type I diabetes patients. CXCL10 was significantly up-regulated in the salivary glands of patients with Sjögren's Syndrome. It also has been reported that CXCL10 was increased in the urine of patients with pulmonary diseases in the absence of renal dysfunction. Both the ELISA MAX™ Set Standard and ELISA MAX™ Set Deluxe are specifically engineered for accurate recovery and measurement of analytes in complex fluids, such as serum and plasma (as well as activated cell cultures) without any interference by confounding serum factors, such as heterophilic antibody or rheumatoid factor.
10plates
Verified Reactivity: Human
Application: ELISA
Application References(PubMed link indicates BioLegend citation): Abou El Hassan M, et al. 2015. PLoS One.10:126466. PubMed
Product Citations: Di Nitto C, et al. 2023. Pharmaceutics. 15:. PubMed Fionda C, et al. 2022. Front Immunol. 13:1039120. PubMed Hassan M, et al. 2015. PLoS One. 10:126466. PubMed AbuSamra DB, et al. 2021. Cells. 10:. PubMed Henrich IC, et al. 2021. Cancer Res. 81:2171. PubMed Read SA, et al. 2021. J Inflamm Res. 14:1257. PubMed Millrine D, et al. 2016. Proc Natl Acad Sci U S A. 113: 10625 - 10630. PubMed Luteijn RD, et al. 2019. Nature. 573:434. PubMed Congy-Jolivet N, et al. 2022. EBioMedicine. 80:104047. PubMed Huang YC, et al. 2021. Toxins (Basel). 13:. PubMed
Sensitivity: 4 pg/mL
Standard Range: 15.6-1,000 pg/mL
Cell Sources: Monocytes, macrophages, fibroblasts, and epithelial cells
Biology Area: Cell Biology, Signal Transduction
Molecular Family: Cytokines/Chemokines, Growth Factors
Gene ID: 3627
UniProt: View information about CXCL10 on UniProt.org
Regulatory Status: RUO
Other Names: Interferon gamma-inducible protein 10 (IP10), Interferon gamma induced factor, gIP-10, IFI10, INP10, CXCL10 Precoated ELISA Kit
Q: Do the ELISA MAX™ Deluxe Sets come with plates?
A: No, ELISA MAX™ Deluxe Sets do not come with plates. Coating Buffer and Assay Diluent (for blocking and dilutions) are included in these sets. Plates can be ordered separately (Cat No. 423501), and instructions for coating the plates are in the sets’ product manuals.