Biolegend, 440804, ELISA MAX™ Deluxe Set Human CCL5 (RANTES), 5plates

Please contact our sales representative for bulk pricing quotations. CCL5, also known as RANTES, is a member of the CC family of chemokines. The precursor of CCL5 contains 91 amino acids, with an N-terminal signal peptide of 23 amino acids which is cleaved to generate the 68 amino acids mature protein (7.8 kD). Human mature CCL5 shares 82% - 90% amino acid seqeuence identity with equine, porcine, bovine, mouse, rat and canine CCL5. CCL5 is expressed by T cells and monocytes/macrophages. It plays an active role in recruiting leukocytes into inflammatory sites through receptors CCR1, CCR3, CCR4, and CCR5. CCL5 induces the proliferation and activation of certain natural killer (NK) cells. It also inhibits HIV-1 entry and infection. In addition, CCL5 plays a crucial role in the migration and metastasis of cancer cells. Increased CCL5 levels are found in melanoma, breast, cervical, prostate, gastric, and pancreatic cancers. Both the ELISA MAX™ Set Standard and ELISA MAX™ Set Deluxe are specifically engineered for accurate recovery and measurement of analytes in complex fluids, such as serum and plasma (as well as activated cell cultures) without any interference by confounding serum factors, such as heterophilic antibody or rheumatoid factor.
5plates
Verified Reactivity: Human
Application: ELISA
Product Citations: Anand A, et al. 2020. Carcinogenesis. . PubMed Kirchhammer N, et al. 2022. Sci Transl Med. 14:eabm9043. PubMed Chabanon RM, et al. 2019. J Clin Invest. 129:1211. PubMed Yang JH, et al. 2021. Molecules. 26:. PubMed He X, et al. 2021. Cell Rep. 36:109392. PubMed Patsouras M, et al. 2015. J Autoimmun. Available online 15 August 2015. PubMed
Sensitivity: 3 pg/mL
Standard Range: 7.8-500 pg/ml
Cell Sources: T cells, monocytes/macrophages, mesangial cells, platelets
Biology Area: Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience
Molecular Family: Cytokines/Chemokines
Gene ID: 6352
UniProt: View information about CCL5 on UniProt.org
Regulatory Status: RUO
Other Names: D17S136E, SCYA5, SISd, TCP228
Q: Do the ELISA MAX™ Deluxe Sets come with plates?
A: No, ELISA MAX™ Deluxe Sets do not come with plates. Coating Buffer and Assay Diluent (for blocking and dilutions) are included in these sets. Plates can be ordered separately (Cat No. 423501), and instructions for coating the plates are in the sets’ product manuals.