Biolegend, 519506, APC anti-human CXCL10 (IP-10) Antibody, 100tests

CXCL10, also known as IP-10, is a 8.7 kD chemokine. It belongs to the CXC chemokine family. It is expressed by monocytes, fibroblasts, and endothelial cells in response to IFNγ. It can interact with CXCR3 and plays an important role in immune cell trafficking, particularly of T cells, dendritic cells, and NK cells. In addition, it alters expression of adhesion molecules.
100tests
Verified Reactivity: Human
Reported Reactivity: Rhesus
Antibody Type: Monoclonal
Host Species: Mouse
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: ICFC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Excitation Laser: Red Laser (633 nm)
RRID: AB_2904431 (BioLegend Cat. No. 519505) AB_2904431 (BioLegend Cat. No. 519506)
Structure: CXC chemokine family, 8.7 kD
Distribution: Monocytes, endothelial cells, and fibroblasts
Function: Interacts with CXCR3 and serves as a chemoattractant for T cells, dendritic cells, monocytes/macrophages, and NK cells
Ligand/Receptor: CXCR3
Cell Type: B cells, Dendritic cells, Endothelial cells, Fibroblasts, Monocytes
Biology Area: Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience
Molecular Family: Cytokines/Chemokines
Antigen References: 1. Luster AD, et al. 1987. Proc. Natl. Acad. Sci. USA 84:2868. 2. Kaplan G, et al. 1987. J. Exp. Med. 166:1098. 3. Sarris AH, et al. 1993. J. Exp. Med. 178:1127.
Gene ID: 3627
UniProt: View information about CXCL10 on UniProt.org
Clone: J034D6
Regulatory Status: RUO
Other Names: Interferon gamma induced protein-10 (IP-10)
Isotype: Mouse IgG2a, κ