Biolegend, 602552, Purified anti-RSK1 Antibody, 100μg

Ribosomal protein S6 kinase α1 (RPS6KA1), most commonly known as RSK1, is a serine/threonine kinase that acts downstream of ERK/MAPK signaling. Upon activation, RSK1 translocates to the nucleus where it controls the activity of several important transcription factors, such as CREB1 and c-FOS. Additionally, RSK1 directly controls translation through phosphorylation of the transcriptional protein RPS6 and EIF4B. Through these roles, RSK1 is involved in the control of cellular growth and proliferation, and genetic variants of RSK1 have been implicated in multiple cancer types.
100μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Purified recombinant RSK1 fragments
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.25 - 1.0 µg/mL. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: This clone does not recognize mouse RSK1 in Western Blot
RRID: AB_2910476 (BioLegend Cat. No. 602551) AB_2910476 (BioLegend Cat. No. 602552)
Structure: RSK1 is a 735 amino acid protein with a predicted molecular weight of 83 kD.
Distribution: RSK1 is widely expressed in most tissues and cell types with primarily cytosolic localization.
Function: Kinase, regulates transcription and translation
Interaction: SRF, c-Fos, CREB1, ERK, NFATc4, MITF, ER81
Biology Area: Cell Proliferation and Viability, Protein Synthesis, Transcription Factors
Molecular Family: Protein Kinases/Phosphatase
Antigen References: Anjum R, et al. 2008. Nat Rev Cell Biol. 9:747-58.
Gene ID: 6195
UniProt: View information about RSK1 on UniProt.org
Clone: 6B9-D6-F8
Regulatory Status: RUO
Other Names: Ribosomal protein S6 kinase alpha-1, 90kD ribosomal protein S6 kinase 1, MAP kinase-activated protein kinase 1a, Ribosomal S6 kinase 1, HU-1, P90-RSK1
Isotype: Mouse IgG1, κ