Biolegend, 612155, Biotin anti-human YKL-40 (CHI3L1) Antibody, 50μg

YKL-40, also known as CHI3L1 (Chitinase-3-like protein 1) or cartilage glycoprotein-39 (GP-39) is secreted by chondrocytes, synoviocytes, endothelial cells, smooth muscle cells and immune cells. YKL-40 plays a major role in different physiological processes including cell proliferation, tissue remodeling, angiogenesis, and apoptosis. Elevated serum levels of YKL-40 are linked to the pathogenesis and prognosis of several inflammatory reactions and autoimmune diseases, such as cancer, rheumatoid arthritis, liver cirrhosis, diabetes, and inflammatory bowel disease. Higher YKL-40 levels in cerebral spinal fluid are a known biomarker of brain inflammation and have a potential prognostic utility as a disease-specific marker in neurodegenerative disorders.
50μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Human Recombinant CHI3L1 Protein
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
Application: Direct ELISA - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by Direct ELISA. The optimal concentration of this reagent for the specific application and the experiment design should be established by the end-user.
Additional Product Notes: This product is intended for sandwich-based immunoassay development on various assay platforms requiring antibody pairs. This antibody (clone A19120F) could function as a detection antibody when paired with purified anti-human YKL-40 (CHI3L1) antibody (Cat No. TBD) (clone W19120B) as the capture antibody and using Recombinant Human Chitnase 3-like 1 (carrier-free) (Cat No. 56802 and 568706) protein as the assay standard. For assay development flexibility purposes, this product is provided as a biotin format.
RRID: AB_3720582 (BioLegend Cat. No. 612155)
Structure: Monomer
Distribution: Dendritic cells, Macrophages
Interaction: Macrophages, Neutrophils, T cells
Ligand/Receptor: IL-13Rα2, Syndecan-1
Cell Type: Endothelial cells, Granulocytes, Leukemia, Macrophages, Neurons
Biology Area: Cancer Biomarkers, Cell Motility/Cytoskeleton/Structure, Cell Proliferation and Viability
Molecular Family: Enzymes and Regulators
Gene ID: 1116
UniProt: View information about YKL-40 on UniProt.org
Clone: A19120F
Regulatory Status: RUO
Other Names: Chitnase-3-like protein 1, CHIL3L1, YKL-40, Cartilage glycoprotein 39, CGP-39, GP-39
Isotype: Mouse IgG1, κ
Q: How many biotin molecules are per antibody structure?
A: We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.