Biolegend, 614552, Purified anti-CRMP5 Antibody, 100μg

CRMP5 (Collapsin Response Mediator Protein 5 or DPYSL5) is a member of the CRMP family and is involved in regulation of the cytoskeleton. CRMP5 acts as a negative regulator of microtubule stability and dynamics and participates in the fibroblast growth factor (FGF) signaling pathway, regulating axon guidance and neuronal development. CRMP5 has been implicated in several human diseases. In cancer cells, CRMP5 regulates cancer cell migration, invasion, and proliferation through its interaction with the tumor suppressor protein, PTEN. Mutations in CRMP5 are related to neurodevelopmental disorders, including X-linked intellectual disability and autism spectrum disorder. CRMP5 regulates tau protein degradation through its interaction with microtubules and enzymes, suggesting its role in neuroinflammation and Alzheimer's disease.
100μg
Verified Reactivity: Human, Mouse
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Recombinant fragment of CRMP5
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: IHC-P - Quality tested WB - Verified
Recommended Usage: Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 1.0 - 10.0 µg/mL is suggested. For western blotting, the suggested use of this reagent is 0.1 - 1.0 µg/mL. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: This product is not recommended for use in immunocytochemistry (ICC). For use in immunohistochemistry (IHC), antigen retrieval with Tris-EDTA pH 9.0 is recommended.
RRID: AB_2941617 (BioLegend Cat. No. 614551) AB_2941617 (BioLegend Cat. No. 614552)
Structure: Forms homotetramer and heterotetramer with the other CRMP proteins
Distribution: Cytoplasm; expressed in Neuronal tissue and lung
Function: Regulate cytoskeleton stability and dynamics; axon guidance
Interaction: Interact with other CRMP proteins, MAP2, TUBB3
Cell Type: Mature Neurons, Neural Stem Cells, Neurons
Biology Area: Apoptosis/Tumor Suppressors/Cell Death, Cancer Biomarkers, Neurodegeneration, Neuroinflammation, Neuroscience, Synaptic Biology
Molecular Family: APP/Aβ Degradation, Microtubules, Tau
Antigen References: Yu Z, et al. 2001. Ann Neurol. 49:146-54. Bretin S, et al. 2005. J Comp Neurol. 486:1-17. Yamashita N, et al. 2011. J Neurosci. 31:1773-9. Lin YS, et al. 2019. Neuropharmaology. 157:107673.
Gene ID: 56896
UniProt: View information about CRMP5 on UniProt.org
Clone: A18231D
Regulatory Status: RUO
Other Names: Collapsin Response Mediator Protein 5, Dihydropyrimidinase Like 5, DPYSL5, DRP-5, UNC33-Like Phosphoprotein 6, Ulip6
Isotype: Mouse IgG2b, κ