Biolegend, 615101, Purified anti-RelB Antibody, 25μg

The Nuclear Factor kappa-light chain-enhancer of activated B cell, or NF- κB, is a transcriptional complex that plays a critical role in inducing expression of genes involved in inflammation, stress responses, cell growth, and apoptosis. The functional NF- κB complex can be comprised of homo- or heterodimeric units of Rel-like/homology domain containing proteins, including RelA, RelB, cRel, p50 and p52. RelB, which preferentially forms heterodimers with p50 and p52, is associated with non-canonical NF- κB signaling activation. This branch of NF- κB signaling is characterized by the NF-κB-inducing kinase (NIK)-linked processing of p100 instead of degradation of IκBα. Non-canonical NF-κB signaling is crucial for B-cell survival and maturation, and overexpression of RelB is associated with lymphoid malignancies and colorectal tumorigenesis.
25μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Partial recombinant human RelB protein corresponding to amino acid residues 69-308
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.125 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: This clone may produce a ~65 kD non-speccific band by WB when used at higher concentrations.This clone does not recognize mouse RelB.
RRID: AB_2814454 (BioLegend Cat. No. 615101) AB_2814455 (BioLegend Cat. No. 615102)
Structure: RelB is a 579 amino acid protein with a predicted molecular weight of 62 kD.
Distribution: Ubiquitously expressed; nuclear and cytosolic localization.
Function: Transcriptonal regulator
Cell Type: Hematopoietic stem and progenitors
Biology Area: Transcription Factors
Antigen References: Beg AA, et al. 1992. Genes Dev. 6: 1899 Lernbecher T, et al. 1993. Nature. 365: 767. Lernbecher T, et al. 1994. EMBO J. 13:4060. Sun SC. 2011. Cell Res. 21: 71 Tao Y, et al. 2018. Ongogene. 37:5887
Gene ID: 5971
UniProt: View information about RelB on UniProt.org
Clone: W16195A
Regulatory Status: RUO
Other Names: IREL, IMD53
Isotype: Rat IgG2a, κ