Biolegend, 615401, Purified anti-NFATC4 Antibody, 25μg

NFATC4 is a transcriptional activator that induces expression of cytokine genes, including IL2 and IL4 in activated T cells. It also plays a central role in cardiovascular, muscle, and nervous cell development, differentiation, and function. Under basal conditions, NFATC4 is extensively phosphorylated and retained in the cytosol. Upon stimulation, elevated calcium results in NFATC4 dephosphorylation by calcineurin and subsequent translocation into the nucleus.
25μg
Verified Reactivity: Human, Mouse
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Partial recombinant human NFATC4 protein corresponding to amino acids 887-902
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.25 - 1.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: This clone displayed a weak affinity for mouse NFATC4 when tested by WB.
RRID: AB_2814456 (BioLegend Cat. No. 615401) AB_2814457 (BioLegend Cat. No. 615402)
Structure: The canonical isoform of NFATC4 is a 902 amino acid protein with a predicted molecular weight of 95 kD. Several isoforms of NFATC4 have been reported.
Distribution: Cells of the immune, nervous, and muscle system/nucleo-cytoplasmic localization
Function: Transcription factor
Cell Type: T cells
Biology Area: Transcription Factors
Antigen References: Graef IA, et al. 2003. Cell. 113: 657. Crabtree GR, et al. 1999. Cell. 96:611. Lyakh L, et al. 1997. Mol Cell Biol. 17: 2475
Gene ID: 4776
UniProt: View information about NFATC4 on UniProt.org
Clone: W17026A
Regulatory Status: RUO
Other Names: NFAT3, Nuclear factor of activated T-cells, cytoplasmic 4
Isotype: Rat IgG2a, κ