Biolegend, 616351, Purified anti-Glycodelin Antibody, 25μg

Glycodelin, also known as progesterone-associated endometrial protein (PAEP), belongs to the lipocalin family and exists in four glycoforms. The glycodelin isoforms are primarily expressed in different reproductive tissues, such as glycodelin-S in male seminal vesicles, glycodelin-A (GdA) in the endometrium, glycodelin-F (GdF) in fallopian tubes/follicular fluid, and glycodelin-C (GdC) in cumulus cells. Glycodelin isoforms are involved in reproductive processes such as implantation, fertilization, and pregnancy maintenance. GdA plays a crucial role in differentiating natural killer (NK) cells to decidual NK cells and modulating the NK cells to prevent maternal immune rejection during embryo development. At the feto-maternal interface, GdA inhibits the proliferation of T-cells and induces their apoptosis through Th receptors. GdC is converted from GdA and GdF through glycosylation modification and facilitates sperm-zona pellucida binding. Recently, abnormal glycodelin expression has been observed in various cancers, including ovarian, breast, colon, and lung cancers. Mice xenograft models have revealed that glycodelin plays a role in tumor proliferation and invasion.
25μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Recombinant fragment of human glycodelin
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.25 - 1.0 µg/mL. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: This product is not recommended for use in immunohistochemistry.
RRID: AB_2941624 (BioLegend Cat. No. 616351) AB_2941624 (BioLegend Cat. No. 616352)
Structure: Forms four glycoforms, glycodelin-S, -A, -F and -C; homodimer
Distribution: Expressed in and secreted by reproductive tissues
Function: Participates in reproductive processes, including implantation, fertilization, and pregnancy maintenance
Interaction: A2M, SIGLEC6
Biology Area: Immunology
Antigen References: Seppala M, et al. 2007. Hum Reprod Update. 3:275-87. Ren S, et al. 2010. J Cell Mol Med. 4:1432-42. Lee C-L, et al. 2011. J Repord Immunol. 90:29-34. Cui J, et al. 2017. Front Immunol. 8:1685. Lee C-L, et al. 2019. Hum Reprod. 34:689-701.
Gene ID: 5047
UniProt: View information about Glycodelin on UniProt.org
Clone: A16006H
Regulatory Status: RUO
Other Names: Placental protein 14, PP14, Progestagen-associated endometrial protein, Progesterone-associated endometrial protein, PAEP, Zona-binding inhibitory factor-1. ZIF-1, Pregnancy-associated endometrial alpha-2 globulin, PAEG, PEG
Isotype: Mouse IgG2b, κ