Biolegend, 635752, Purified anti-RET Antibody, 100μg

The proto-oncogene RET encodes a transmembrane tyrosine-protein kinase receptor that is involved in several cellular mechanisms such as proliferation, migration, neuronal navigation, and cell differentiation. RET is important in the development of the nervous system, as well as in the formation of organs and tissues derived from the neural crest. The interaction with the ligand glia cell-line derived neurotrophic factor (GDNF), is vital for promoting cell survival. Conversely, in the absence of GDNF the receptor becomes active and induces apoptosis. Oncogenic activation of RET by either cytogenetic rearrangement or activating mutations, is associated to various diseases such as Hirschsprung disease, central hypoventilation syndrome, and multiple endocrine neoplasia type IIA and type IIB.
100μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Recombinant fragment of RET protein
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.5 - 1.0 µg/mL. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_3106121 (BioLegend Cat. No. 635751) AB_3106121 (BioLegend Cat. No. 635752)
Structure: RET gene encodes a 1114 amino acid protein of around 124 kD.
Distribution: Cellular and endosomal membranes
Function: Receptor tyrosine-protein kinase
Interaction: PLCG1 and GRB7, PTK2/FAK1, AIP, ARTN, DOK2, DOK4, DOK5, GFRAL, GFRA1, GDNF
Ligand/Receptor: GDNF
Biology Area: Cancer Biomarkers, Cell Biology, Cell Death
Antigen References: Novello S, et al. 2023. Oncologist. 28:402-413. Subbiah V, et al. 2020. J Clin Oncol. 38:1209-1221. Regua AT, et al. 2022. Front Oncol. 12:932353. Addeo A, et al. 2023. Pharmacol Ther. 242:108344.
Gene ID: 5979
UniProt: View information about RET on UniProt.org
Clone: W22020E
Regulatory Status: RUO
Other Names: CDHF12, CDHR16, PTC, RET51, Proto-oncogene tyrosine-protein kinase receptor Ret, RET receptor Tyrosine Kinase, RET tyrosine kinase receptor, proto-oncogene C-Ret, , RET-ELE1, RET9, Cadherin Family member 12
Isotype: Rat IgG2b, κ