Biolegend, 667901, Purified anti-ETS1 Antibody, 25μg

ETS1 is a transcription factor that regulates gene transcription of cytokine and chemokine genes. The expression of ETS1 is modulated by transcription factors and kinases. It is expressed in lymphoid organs where it may  play a role in cell differentiation, survival, and proliferation. The ETS1 gene encodes multiple proteins by  alternative splicing of mRNA, resulting in at least six distinctive isoforms; the major species are p51, p48, p42, and p39. In certain cancers, elevated ETS1 expression is a predictive marker of poor prognosis.
25μg
Verified Reactivity: Human, Mouse
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Synthetic human ETS1 peptide surrounding amino acid 170.
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1 - 1.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: W17042D failed ICC testing; PC3 cells were fixed with 4% paraformaldehyde and tested using two permeabilization methods (Methanol and Trition X-100). The clone failed ICC testing due to weak and non-specific staining of cytosol. IP has not been tested on clone W17042D.
RRID: AB_2814508 (BioLegend Cat. No. 667901) AB_2814509 (BioLegend Cat. No. 667902)
Structure: ETS1 is a 441 amino acid protein with a predicted molecular weight of 51 kD.
Distribution: Nucleus/Ubiquitously expressed
Function: Transcription factor that regulates cytoskine and chemokine genes.
Biology Area: Cell Proliferation and Viability, Transcription Factors
Antigen References: Bories JC, et al. 1995. Nature. 377:635-8. Ho IC, et al. 1990. Science. 250:814-8.
Gene ID: 2113
UniProt: View information about ETS1 on UniProt.org
Clone: W17042D
Regulatory Status: RUO
Other Names: ETS-1, ETS proto-oncogene 1, Protein C-ets-1, EWSR2, FLJ10768, p54, ETS Proto-Oncogene 1, V-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog 1
Isotype: Rat IgG2b, κ