Biolegend, 698202, Purified anti-CD106 (VCAM-1) Antibody, 100μg

CD106 is a glycosylphosphatidylinositol (GPI)-linked transmembrane protein, also known as VCAM-1 and INCAM-110. It is constitutively expressed on bone marrow stromal cells, myeloid progenitors, splenic dendritic cells, activated endothelial cells, as well as some lymphocytes. CD106 expression can be upregulated on endothelial cells by inflammatory cytokines. CD106 is involved in adhesion and acts as a counter-receptor for VLA-4 (α4/β1 integrin) and LPAM-1 (α4/β7 integrin).
100μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Human recombinant VCAM-1/FC
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.002 - 0.1 µg/mL (1:5000-1:250000 diluted). It is recommended that the reagent be titrated for optimal performance for each application.
Product Citations: Flaskamp L, et al. 2022. Cells. 11: . PubMed Heesters BA, et al. 2021. J Exp Med. 218:. PubMed
RRID: AB_2687276 (BioLegend Cat. No. 698201) AB_2687285 (BioLegend Cat. No. 698202)
Structure: Ig superfamily, 81 kD. Six N-glycosylation sites, apparent Mw is 90-110kD.
Distribution: Plasma membrane of bone marrow stromal cells, myeloid progenitors, splenic dendritic cells, activated endothelial cells
Function: Important in cell-cell recognition. Function in leukocyte-endothelial cell adhesion.
Interaction: Leukocytes
Ligand/Receptor: VLA-4 (α4/β1 integrin) and LPAM-1 (α4/β7 integrin)
Biology Area: Cell Adhesion, Cell Biology, Immunology, Innate Immunity, Signal Transduction
Molecular Family: Adhesion Molecules, CD Molecules
Antigen References: 1. Barclay AN, et al. 1997. The Leukocyte Antigen FactsBook Academic Press. 2. Kinashi T, et al. 1995. J. Leuko. Biol. 57:168. 3. Bevilacqua MP. 1993. Annu. Rev. Immunol. 11:767. 4. Koni PA, et al. 2001. J. Exp. Med. 193:741.
Gene ID: 7412
UniProt: View information about CD106 on UniProt.org
Clone: A16047A
Regulatory Status: RUO
Other Names: INCAM-110, VCAM1, VCAM 1, Vascular cell adhesion protein 1, V-CAM 1,
Isotype: Mouse IgG2b, κ