Biolegend, 699952, PhosphoPair STAT3 (Tyr705) Antibody Set, 1kit

The STAT (Signal Transducer and Activator of Transcription) proteins represent a family of transcription factors that function as downstream effectors of growth factor and cytokine signaling cascades. STAT3 plays a central role in cell cycle progression, inhibition of apoptosis, and transformation. Phosphorylation of STAT3 at tyrosine 705 by JAK and receptor tyrosine kinases has been shown to increase STAT3 activation through multiple mechanisms, including increased homodimerization and concomitant translocation to the nucleus, as well as through increasing STAT3 affinity for response elements found in the regulatory promoters of its target genes.  High levels of STAT3 activation have been described in several cancers and are of considerable interest for therapeutic intervention.
1kit
Verified Reactivity: Human, Mouse
Immunogen: Please refer to individual product datasheets for immunogen information
Formulation: Phosphate-buffered solutions, pH 7.2, containing 0.09% sodium azide
Preparation: The antibodies were purified by affinity chromatography.
Storage & Handling: The antibody solutions should be stored undiluted between 2°C and 8°C.
Application: WB - Quality tested
Recommended Usage: Each lot of antibodies in this set is quality control tested by Western blotting. For Western blotting, the suggested uses of these reagents are as follows: Clone 4G4B45: 0.25 - 1.0 µg/mL Clone 13A3-1: 0.5 - 1.0 µg/mL It is recommended that the reagent be titrated for optimal performance for each application. For recommended usage information for additional applications, please refer to the datasheet of the individual products.
Structure: STAT3 exists as two isoforms: STAT3α is a 770 amino acid protein with a predicted molecular weight of ~88 kD, STAT3β is a 722 amino acid protein with a predicted molecular weight of ~83 kD.
Distribution: Ubiquitously expressed/Nucleus and cytosol
Function: Cell signaling, transcription factor
Antigen References: 1. Akira S, et al. 1994. Cell 77:63. 2. Zhang X, et al. 1995. Science 267:1990. 3. Sanchez-Margalet V and Martin-Romero C. 2001. Cell. Immunol. 211:30. 4. Simon A, et al. 2000. Science 290:144. 5. Hoey T and Grusby MJ. 1999. Adv. Immunol. 71:145.
Gene ID: 6774
UniProt: View information about STAT3 on UniProt.org
Clone: 4G4B45; 13A3-1;
Regulatory Status: RUO
Other Names: Signal Transducer And Activator Of Transcription 3, Acute-Phase Response Factor, APRF