Biolegend, 855301, Purified anti-Annexin A1, 25μg

Annexin A1 is a member of the annexin family of Ca 2+ -dependent phospholipid-binding proteins. Annexin A1 has been reported to play an important anti-inflammatory role by suppressing phospholipase A2 and blocking eicosanoid production. Expression of Annexin A1 may be  upregulated in the brains of Alzheimer’s diseases patients. Recent studies have demonstrated that Annexin A1 can induce the clearance and degradation of amyloid beta peptide, indicating its potential use as a therapeutic target for Alzheimer’s Disease.
25μg
Verified Reactivity: Human, Mouse
Antibody Type: Monoclonal
Host Species: Mouse
Formulation: 0.01 M PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Application: WB - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1 - 0.5 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
Product Citations: Kumari P, et al. 2023. Nat Cell Biol. 1860:25. PubMed
RRID: AB_2801208 (BioLegend Cat. No. 855301)
Structure: Annexin A1 is a 346 amino acid protein with a molecular mass of ~ 39 kD.
Distribution: Tissue Distribution: Reproduction systems, gastrointestinal tract, lung, immune system, central, and peripheral nervous system. Cellular distribution: Plasma membrane, cytosol, extracellular, nucleus, endosome, and extracellular.
Function: Annexin A1 plays an important role in innate immune response, clearance and degradation of amyloid beta peptide.
Interaction: Annexin A1 forms homodimers and may also interact with S100A11, DYSF, and EGFR.
Biology Area: Protein Misfolding and Aggregation, Protein Trafficking and Clearance, Synaptic Biology
Antigen References: Rentero C, et al. 2018. Int j Mol Sci. 19(5) Perucci LO, et al. 2017. Expert Opin Ther Targets. 21(9):879 Boudhraa Z, et al. 2016. Clin Sci. 130(4):205
Gene ID: 30116952
UniProt: View information about Annexin A1 on UniProt.org
Clone: BL28553
Regulatory Status: RUO
Other Names: ANXA1, Annexin A1
Isotype: Mouse IgG2b, κ