Biolegend, 856302, Purified anti-Transthyretin Antibody, 100μg

Transthyretin (TTR) is a carrier protein capable of transporting thyroid hormones in the plasma and cerebrospinal fluid, and retinol (vitamin A) in the plasma. TTR can form aberrant, insoluble amyloid fibrils that primarily deposit in a patient's heart, peripheral nerves, or both. The wild-type protein is associated with senile systemic amyloidosis (SSA) and is typically diagnosed in men over 70-years-old. Single or double mutations in TTR are primarily associated with familial amyloidotic polyneuropathy (FAP) or familial amyloid cardiopathy (FAC) which affects younger patients, often in their 30s. Clinical symptoms of TTR amyloidosis have historically been attributed to fibrils, but recent experimental evidence indicates that soluble TTR aggregates are also pathogenic.
100μg
Verified Reactivity: Human, Mouse, Rat
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: TTR-KLH peptide
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality testedIHC-P - Verified
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 10 µg per ml. For immunohistochemistry on formalin-fixed paraffin-embedded tissue, a concentration range of 1.0 - 10 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2783454 (BioLegend Cat. No. 856301) AB_2783455 (BioLegend Cat. No. 856302)
Structure: Transthyretin (TTR) is a β-sheet rich homotetrameric protein that has a molecular mass of 55 kD. Each monomer consists of 147 amino acids.
Distribution: Primarily extracellular in blood and cerebrospinal fluid.
Function: The normal function of TTR is to transport thyroxine and retinol-binding protein in the blood and cerebrospinal fluid.
Interaction: Perlecan, receptor for advanced glycation end product (RAGE).
Cell Sources: Liver, choroid plexus epithelium, retina pigment epithelium.
Biology Area: Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation
Molecular Family: Carrier Proteins
Antigen References: Groenning M. et al. 2015. Sci. Rep. 5:11443. Saelices L. et al. 2015. J. Biol Chem. 290, 28932-43.
Gene ID: 7276
UniProt: View information about Transthyretin on UniProt.org
Clone: A16143A
Regulatory Status: RUO
Other Names: TTR, ATTR, Prealbumin, TBPA, PALB
Isotype: Mouse IgG1, κ