Biolegend, 862101, Purified anti-ApoER2 (LRP8) Antibody, 25μg

LDL Receptor Related Protein 8 (LRP8), also known as ApoER2, is a receptor for members of low-density lipoproteins. LRP8 interacts with its ligand reelin, and triggers reelin signaling to regulate cellular processes such as neuronal cell migration and long-term potentiation of mature neurons. LRP8 also interacts with and downregulates APP endocytosis. This interactions leads to increased amyloid beta production, demonstrating a major role for LRP8 in the pathogenesis of  Alzheimer’s disease.
25μg
Verified Reactivity: Human, Mouse, Rat
Antibody Type: Monoclonal
Host Species: Rat
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 2 - 10 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2801239 (BioLegend Cat. No. 862101) AB_2801240 (BioLegend Cat. No. 862102)
Structure: LRP8 is a 963 amino acid protein with an apparent molecular mass of ~105 kD.
Distribution: Tissue Distribution: brain, endocrine tissue, testis, and placenta Cellular Distribution: plasma membrane, extracellular, and cytoskeleton
Function: LRP8 functions as the receptor for reelin. Binding and endocytosis of reelin triggers downstream signaling pathways that affects neuronal migration and postnatal LTP.
Interaction: FE65, JIP1, JIP2, Thrombosphondin, F-Spondin
Cell Type: Neurons
Biology Area: Neurodegeneration, Neuroscience, Protein Trafficking and Clearance
Molecular Family: Apolipoproteins
Antigen References: Santana J and Marzolo MP. 2017. Biochem J. 474(18):3137 Kim J, et al. 2014. Mol Cells. 37(11):767 Lara-Castillo N and Johnson ML. 2015. Rev Endocr Metab Disord. 16(2):141
Gene ID: 780416975
UniProt: View information about ApoER2 on UniProt.org
Clone: 25G5
Regulatory Status: RUO
Other Names: LRP8, APOER2, LDL Receptor Related Protein 8
Isotype: Rat IgG2a, κ