Biolegend, 865601, Purified anti-Parkin Antibody, 25μg

Parkin (also known as PARK2, AR-JP, PRKN) is a protein encoded by the PARK2 gene in humans. It is a component of the E3 ubiquitin ligase complex that mediates the targeting of proteins for degradation. Mutations in the PARK2 gene cause a familial form of Parkinson’s disease called autosomal recessive juvenile Parkinson’s disease (AR-JP).
25μg
Verified Reactivity: Human, Mouse, Rat
Antibody Type: Monoclonal
Host Species: Mouse
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 5.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2810777 (BioLegend Cat. No. 865601) AB_2810778 (BioLegend Cat. No. 865602)
Structure: Parkin is a 465 amino acid protein with an apparent molecular mass of ~ 52 kD.
Distribution: Tissue Distribution: Brain, heart, testis, and skeletal muscle. Cellular Distribution: Cytosol, mitochondria, nucleus, and endoplasmic reticulum.
Function: Parkin in involved in protein ubiquitination, protein degradation, mitochondria function, and neurodegeneration.
Interaction: Ubiquitin, PINK1
Ligand/Receptor: BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1
Cell Type: Astrocytes, Microglia, Neurons, Oligodendrocytes
Biology Area: Cell Biology, Mitochondrial Function, Neurodegeneration, Neuroinflammation, Protein Misfolding and Aggregation, Ubiquitin/Protein Degradation
Molecular Family: Enzymes and Regulators, Ligases
Antigen References: Tay SP, et al. 2018. J Biol Chem. 285: 29231-29238. Pawlyk AC, et al. 2003. J Biol Chem. 278(48):48120-8.
Gene ID: 5071
UniProt: View information about Parkin on UniProt.org
Clone: 5C3/Parkin
Regulatory Status: RUO
Other Names: PARK2, AR-JP, LPRS2, PDJ, PRKN, E3 ubiquitin-protein ligase parkin, Parkin 2, E3 ubiquitin ligase, parkinson disease protein 2, parkinson juvenile disease protein 2, Parkinson disease (autosomal recessive, juvenile) 2
Isotype: Mouse IgG1, κ