Biolegend, 866307, Alexa Fluor® 488 anti-Galectin-7 Antibody, 25μg

The galectins are a family of beta-galactoside-binding proteins implicated in cell-cell and cell-matrix interactions. Galectin-7 is specifically expressed in stratified epithelia and epidermis, but barely detected in epidermal tumors and absent from squamous carcinoma cell lines. Galectin-7 is a p53-induced protein and is abnormally expressed in variety of tumors such as melanoma, lung cancer and colon cancer. In UVB-induced sunburn keratinocytes, the expression of Galectin-7 is markedly increased due to the genotoxic stress-induced p53 activation. Both positive and negative regulatory roles of Galectin-7 have been reported in tumorigenesis.
25μg
Verified Reactivity: Human, Mouse
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Recombinant human Galectin-7
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 488 under optimal conditions.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: IHC-P - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 0.5 - 10 µg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application. * Alexa Fluor® 488 has a maximum emission of 519 nm when it is excited at 488 nm. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses
Excitation Laser: Blue Laser (488 nm)
RRID: AB_2861101 (BioLegend Cat. No. 866307) AB_2861102 (BioLegend Cat. No. 866308)
Structure: Human Galectin-7 is a 136 amino acid protein with a molecular mass of 15 kD.
Distribution: Tissue distribution: Stratified squamous epithelium Cellular distribution: Nucleus, extracellular region or secreted, and cytoplasm
Function: Galectin-7 is involved in the cell-cell and cell-matrix interactions.
Ligand/Receptor: Carbohydrates
Cell Type: Epithelial cells
Biology Area: Cancer Biomarkers, Cell Adhesion, Cell Biology, Neurodegeneration
Molecular Family: Adhesion Molecules, Soluble Receptors
Antigen References: Bernerd F. et al. 1999. Proc Natl Acad Sci U S A. 96(20):11329-34. Madsen P. et al. 1995. J Biol Chem. 270(11):5823-9. Biron-Pain K. et al. 2013. PLoS One. 8(5):e63307.
Gene ID: 3963
UniProt: View information about Galectin-7 on UniProt.org
Clone: A18059A
Regulatory Status: RUO
Other Names: Galectin 7, Gal-7, GAL7, HKL-14, PI7, PIG1, p53-induced gene 1 protein, TP53I1, LGALS7A
Isotype: Rat IgG2a, κ