Biolegend, 866802, Purified anti-ALDH2 Antibody, 100μg

ALDH2 is a member of the aldehyde dehydrogenase family. In the human brain, ALDH2 is the major aldehyde metabolizing enzyme that is essential for the metabolism and detoxification of endogenous and exogenous aldehyde substrates. In line with this, recent studies have reported that ALDH2 level is dysregulated in the brains of patients with Parkinson’s and Alzheimer's diseases, suggesting toxic aldehydes as a contributing factor to neurodegenerative diseases and a potential therapeutic target.
100μg
Verified Reactivity: Human, Mouse, Rat
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Purified recombinant human ALDH2 fragments expressed in E. coli.
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality testedIHC-P - Verified
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per ml. For immunohistochemistry, a concentration range of 5.0 - 10 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2810791 (BioLegend Cat. No. 866801) AB_2810792 (BioLegend Cat. No. 866802)
Structure: ALDH2 is a 517 amino acid protein with predicted and observed molecular mass of ~ 56 kD.
Distribution: Tissue Distribution: Mainly expressed in adrenal gland, lung, kidney, and brain Cellular Distribution: Mitochondrion and cytosol
Function: Aldehyde metabolizing enzyme that is essential for the metabolism and detoxification of endogenous and exogenous aldehyde substrates.
Interaction: Forms homo-tetramers
Cell Type: Astrocytes, Microglia, Neurons, Oligodendrocytes
Biology Area: Mitochondrial Function, Neurodegeneration, Neuroinflammation, Neuroscience
Molecular Family: Aldehyde Dehydrogenases, Mitochondrial Markers
Antigen References: Chen CH, et al. 2016. Acta. Neurol. Taiwan. 25(4):111-123. Chauhan G, Debette S. 2016. Curr. Cardiol. Rep. 18(12):124. Grünblatt E, Riederer P. 2016. J. Neural Transm. (Vienna). 123(2):83-90.
Gene ID: 2171166929539
UniProt: View information about ALDH2 on UniProt.org
Clone: 8D4-D6-D11
Regulatory Status: RUO
Other Names: ALDH2, Aldehyde Dehydrogenase 2 Family (Mitochondrial)
Isotype: Mouse IgG1, κ