Biolegend, 866902, Purified anti-PLAP Antibody, 100μg

PLAP is a membrane-bound glycosylated dimeric enzyme that was initially identified in the placenta. PLAP is also known as phospholipase A2 activating protein. Abnormal amyloid beta-induced activation of synaptic phospholipase A2 results in synaptic degeneration due to elevated levels of platelet-activating factor, suggesting that PLAP may be a contributing factor in synaptic damage observed in Alzheimer’s disease patients. Clinically, PLAP is broadly used as a tumor marker, especially in geminoma, seminoma, and ovarian cancer.
100μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: IHC-P - Quality testedWB - Verified
Recommended Usage: Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 2.0 - 10 µg/ml is suggested. For Western blotting, the suggested use of this reagent is 0.5 - 10 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2810793 (BioLegend Cat. No. 866901) AB_2810794 (BioLegend Cat. No. 866902)
Structure: PLAP is a 795 amino acid protein with predicted molecular mass of ~87 kD and observed molecular mass of ~70 kD.
Distribution: Tissue Distribution: Ubiquitously expressed Cellular Distribution: Plasma membrane
Function: Phospholipase A2 activating protein that may be involved in amyloid beta-induced synaptic degeneration.
Interaction: Ubiquitin, UBXN6, VCP, YOD1
Cell Type: Astrocytes, Endothelial cells, Neurons
Biology Area: Cancer Biomarkers, Neurodegeneration, Neuroscience, Synaptic Biology
Molecular Family: Protein Kinases/Phosphatase
Antigen References: Watanabe S et al., 2012. Pediatr Neurosurg. 48(3):141 Bate C et al., 2010. Mol Neurodegener. 5:13 Huynh ML et al., 2011. Genesis. 49(11):851
Gene ID: 18786
UniProt: View information about PLAP on UniProt.org
Clone: 8A11-C11-C9
Regulatory Status: RUO
Other Names: ALPP, PLAA, , Placental Alkaline Phosphatase 1
Isotype: Mouse IgG1, κ