Biolegend, 868302, Purified anti-Fascin-1 Antibody, 100μg

Fascin is a 55 kD F-actin binding protein that is involved in cell motility and migration. Fascin plays an important role in the organization and formation of membrane ruffles, stress fibers, and a diverse set of cell protrusions, such as filopodia. In the mouse subventricular zone-derived migratory neuroblasts, Fascin is highly upregulated to guide the migration of cells along the rostral migratory stream. In Drosophila , Fascin controls neuronal class-specific dendrite arbor morphology to elicit the accurate establishment of neuronal circuits.
100μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Recombinant human Fascin full-length protein
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.2 - 1.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2820172 (BioLegend Cat. No. 868301) AB_2820173 (BioLegend Cat. No. 868302)
Structure: Human Fascin is a 493 amino acid protein with a molecular mass of 54 kD.
Distribution: Tissue distribution: Ubiquitously expressed Cellular distribution: Cytosol, cytoskeleton, and stress fibers
Function: Fascin is involved in the assembly of filamentous actin.
Interaction: Fascin interacts with RUFY3, beta-catenin, and PLXNB3.
Cell Type: Neurons
Biology Area: Cell Biology, Cell Motility/Cytoskeleton/Structure, Neurodegeneration, Neuroscience
Molecular Family: Cytoskeletal Proteins
Antigen References: Yamashiro S, et al. 1998. Mol Biol Cell. 9(5): 993-1006. Nagel J, et al. 2012. Development 139, 2999-3009 Sonego M, et al. 2013. J Neurosci. 33(30): 12171–85.
Gene ID: 6624
UniProt: View information about Fascin-1 on UniProt.org
Clone: CPTC-Fascin1-2
Regulatory Status: RUO
Other Names: FASN1, 55 kDa actin-bundling protein, Singed-like protein, p55
Isotype: Mouse IgG2a, κ