Biolegend, 869001, Purified anti-CRMP2 Antibody, 25μg

CRMP2 is a ubiquitously expressed, microtubule-associated protein. In the central nervous system, CRMP2 forms homotetramers or heterotetramers with other CRMP proteins during development and regulates axonal growth and guidance, neuronal growth cone collapse, and migration. The C-terminal sequence of CRMP2 is highly homologous to that of Tau protein. Phosphorylation of CRMP2 alters its interaction with microtubules and affects its protein scaffolding function. Similar to Tau, CRMP2 is a biochemically prominent component of Neurofibrillary tangles. These finding suggest that CRMP2 may be an etiologically significant protein and a potential therapeutic target for Alzheimer’s disease.
25μg
Verified Reactivity: Human, Mouse, Rat
Antibody Type: Monoclonal
Host Species: Mouse
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality testedIHC-P - Verified
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 1.0 µg per ml. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 0.5 - 1.0 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2814627 (BioLegend Cat. No. 869001) AB_2814628 (BioLegend Cat. No. 869002)
Structure: CRMP2 is a 572 amino acid protein with predicted and observed molecular mass of ~ 63 kD.
Distribution: Tissue Distribution: Ubiquitously expressed Cellular Distribution: Cytosol, plasma membrane, and cytoskeleton
Function: CRMP2 forms homotetramers or heterotetramers with other CRMP proteins, and regulates axonal growth and guidance, neuronal growth cone collapse, and migration.
Interaction: CRMP2 forms homotetramers and heterotetramers with CRMP1, DPYSL3, DPYSL4 or DPYSL5. It interacts with HTR4, CLN6, and, MICALL1.
Cell Type: Astrocytes, Neurons, Oligodendrocytes
Biology Area: Cell Motility/Cytoskeleton/Structure, Neurodegeneration, Neuroinflammation, Neuroscience, Neuroscience Cell Markers, Synaptic Biology
Molecular Family: Cytoskeletal Proteins, Microfilaments, Microtubules, Scaffold Proteins
Antigen References: Hensley K, et al. 2016. J Alzheimers dis. 53(1):1 Quach TT, et al. 2015. Mol Psychiatry. 20(9):1037 Ip JP, et la. 2014. Neuroscientist. 20(6):589
Gene ID: 18081293425416
UniProt: View information about CRMP2 on UniProt.org
Clone: 9F
Regulatory Status: RUO
Other Names: DPYSL2, Collapsin Response Mediator Protein 2, Dihydropyrimidinase-Related Protein 2
Isotype: Mouse IgG2b, κ