Biolegend, 869701, Purified anti-TBL1 Antibody, 25μg

TBL1 is a protein that has sequence similarity with WD40 repeat-containing protein family. TBL1 plays an essential role in signal transduction, gene regulation, vesicle trafficking, and cytoskeletal arrangement through protein-protein interactions. TBL1 is also found as a component of nuclear receptor corepressor complexes through interaction with histone deacetylase 3, and is involved in Notch signaling. It is associated with diseases including ocular albinism and atrial septal defect 4.
25μg
Verified Reactivity: Human, Mouse, Rat
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Purified recombinant human TBL1 protein fragments expressed in E.coli.
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality testedIHC-P - Verified
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 2.0 µg/mL. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 5.0 - 10 µg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2820178 (BioLegend Cat. No. 869701) AB_2820179 (BioLegend Cat. No. 869702)
Structure: TBL1 is a 577 amino acid protein with a predicted and observed molecular mass of ~62 kD.
Distribution: Tissue Distribution: Brain, kidney, liver, heart, and lung Cellular Distribution: Nucleus
Function: TBL1 is involved in the regulation of gene expression, RNA processing, vesicle trafficking, and cytoskeleton assembly.
Interaction: HDAC3, Notch1
Cell Type: Neurons
Biology Area: Cell Biology, Neurodegeneration, Neuroscience, Signal Transduction
Molecular Family: Cytoskeletal Proteins, Nuclear Markers
Antigen References: Perissi V, et al. 2004. Cell. 116(4):511-26. Li J, et al. 2008. Nat Cell Biol. 10(2):160-9.
Gene ID: 690721372302711
UniProt: View information about TBL1 on UniProt.org
Clone: 4H2-D5-E9
Regulatory Status: RUO
Other Names: Transducin Beta Like 1 X-Linked, F-Box-Like/WD Repeat-Containing Protein TBL1X, SMAP55, EBI
Isotype: Mouse IgG2b, κ