Biolegend, 870001, Purified anti-TBLR1 Antibody, 25μg

TBLR1 is a member of the WD40 repeat-containing family of proteins. It shares similarity with TBL1 in sequence, and is believed to be a component of the complex of nuclear corepressor and HDAC3. TBLR1 is involved in signaling pathway during development through the regulation of chromatin acetylation. It is also associated with diseases including pierpont syndrome, mental retardation, and autism spectrum disorders.
25μg
Verified Reactivity: Mouse, Rat
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Purified recombinant human TBLR1 protein fragments expressed in E. coli
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality testedIHC-P - Verified
Recommended Usage: Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.2 - 0.5 µg/mL. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 5.0 - 10 µg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2820184 (BioLegend Cat. No. 870001) AB_2820185 (BioLegend Cat. No. 870002)
Structure: TBLR1 is a 514 amino acid protein with a predicted and observed molecular mass of ~56 kD.
Distribution: Tissue Distribution: Brain, immune system, heart, and lung Cellular Distribution: Nucleus
Function: Chromatin acetylation
Interaction: HDAC3, TBL1, NCOR1, NCOR2, MECP2
Cell Type: B cells, Monocytes, Neurons, NK cells
Biology Area: Cancer Biomarkers, Cell Biology, Neurodegeneration, Neuroscience, Signal Transduction
Molecular Family: Nuclear Markers
Antigen References: Xi X, et al. 2019. Eur J Pharmacol. 844:259-267. Nishi A, et al. 2017. Sci Rep. 7(1):2887.
Gene ID: 81004365755
UniProt: View information about TBLR1 on UniProt.org
Clone: 4F3-A8-D9
Regulatory Status: RUO
Other Names: Transducin Beta Like 1 X-Linked Receptor 1, F-Box-Like/WD Repeat-Containing Protein TBL1XR1, Transducin Beta-Like 1X-Related Protein 1, MRD41, DC42
Isotype: Mouse IgG1, κ