Biolegend, 870702, Purified anti-UBE2V1 Antibody, 100μg

Ubiquitination is a common post-translational modification of proteins and plays an important role in protein homeostasis. UBE2V1 encodes one of the ubiquitin-conjugating E2 enzyme variant proteins (UBE2V), which lacks the conserved cysteine residue required for the catalytic activity of E2s. Elevated expression of UBE2V1 has been associated with tumor development; however, it is not clear whether it functions as an oncogene or tumor suppressor gene. In addition, UBE2V1 is a key component in TRAF6 to control NF-κB activation.
100μg
Verified Reactivity: Human, Mouse, Rat, Drosophila
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Recombinant human UBE2V1 protein
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 1.0 - 10 µg/mL. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2832874 (BioLegend Cat. No. 870701) AB_2832875 (BioLegend Cat. No. 870702)
Structure: Human UBE2V1 is a 147 amino acid protein with a predicted molecular mass of 16 kD.
Distribution: Tissue distribution: Ubiquitously expressed Cellular distribution: Cytosol, nucleus
Function: UBE2V1 is a ubiquitin-conjugating enzyme.
Cell Type: Astrocytes, Neurons
Biology Area: Cell Biology, Cell Cycle/DNA Replication, Neuroinflammation, Neuroscience, Protein Trafficking and Clearance, Ubiquitin/Protein Degradation
Molecular Family: Enzymes and Regulators, Ligases
Antigen References: Ma L, et al. 1998. Oncogene. 17:1321-6. Shen T, et al. 2018. J. Hematol. Oncol. 11:95. Wu X, Karin M. 2015. Immunol. Rev. 266:161-74.
Gene ID: 7335
UniProt: View information about UBE2V1 on UniProt.org
Clone: A18196A
Regulatory Status: RUO
Other Names: Ubiquitin-conjugating enzyme E2 variant 1, UEV-1, CROC-1, TRAF6-regulated IKK activator 1 beta Uev1A
Isotype: Mouse IgG2a, κ