Biolegend, 871401, Purified anti-Calretinin Antibody, 25μg

Calretinin is a calcium-binding protein that is abundantly expressed in interneurons and multiple regions of the brain, including the brainstem, hypothalamus, hippocampus, and cerebellum. Calretinin is involved in regulating intracellular calcium signaling and modulating neuronal excitability. Loss and reorganization of calretinin-positive interneurons have been indicated as possible cause in human epilepsy. In addition, calretinin is considered as the most sensitive and specific marker for the diagnosis of malignant mesothelioma.
25μg
Verified Reactivity: Human, Mouse, Rat
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Recombinant human CALB2
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.1 - 2.0 µg/mL. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2861109 (BioLegend Cat. No. 871401) AB_2861110 (BioLegend Cat. No. 871402)
Structure: Human calretinin is a 271 amino acid protein with a predicted molecular mass of 31 kD.
Distribution: Tissue distribution: Brain Cellular distribution: Cytosol, cytoskeleton, nucleus, plasma membrane
Function: Calretinin regulates intracellular calcium signaling and modulates neuronal excitability.
Cell Type: Neurons
Biology Area: Cell Biology, Neuroinflammation, Neuroscience, Synaptic Biology
Antigen References: Wörthmüller J, et al. 2018. Oncotarget. 9(91):36256-36272. Christel CJ, et al. 2012. J Biol Chem. 287(47):39766-75. Tóth K, et al. 2010. Brain. 133(9):2763-77.
Gene ID: 794
UniProt: View information about Calretinin on UniProt.org
Clone: A18241B
Regulatory Status: RUO
Other Names: CR, 29 KDa calbindin, CAB29, CALB2, Calbindin 2, Calbindin D29K, CAL2
Isotype: Mouse IgG2b, κ