Biolegend, 919001, Purified anti-HIV TAT Antibody (Previously Covance catalog# MMS-116P), 250microl

The HIV-1 TAT (transactivator of transcription) gene codes for a 14 kD protein and is vital for HIV-1 transcription. After infection, TAT is one of the first proteins expressed after HIV has taken over the host’s machinery. TAT is a RNA binding protein that recognizes the TAR (Transactivator Response Element) sequence found in the HIV-1 RNA molecule. It is also needed for the recruitment of the host positive transcription elongation factor b (p-TEFb). In neuron cells, TAT has been linked to progressive neuronal deregulation, HIV-Associated Neurocognitive Disorders and accelerating brain aging.
250microl
Verified Reactivity: HIV
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: This antibody was generated against full-length HIV TAT protein.
Formulation: Phosphate-buffered solution + 0.03% Thimerosal.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 1 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.
Application: WB
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. The optimal working dilution should be determined for each specific assay condition. • WB: 1:1,000*
Application Notes: This antibody is effective in immunoblotting (WB). *Predicted MW = 11 kD The epitope is contained in the first 37 amino acids of the protein.
Product Citations: Hategan A, et al. 2017. Nat Struct Mol Biol. 10.1038/nsmb.3379. PubMed
RRID: AB_2565207 (BioLegend Cat. No. 919001)
Biology Area: Bacterial proteins and Toxins, Cell Biology
Gene ID: 155871
UniProt: View information about HIV TAT on UniProt.org
Clone: AC11.AE12
Regulatory Status: RUO
Other Names: HIV TAT
Previously: Covance Catalog# MMS-116P
Isotype: Mouse IgG1