Biolegend, 943301, Purified anti-β-Amyloid, 1-38 Recombinant Antibody, 25μg

Amyloid beta (Aβ or Amyloid beta) denotes peptides of 36-43 amino acids in length that are crucially involved in Alzheimer's disease as the main component of the amyloid plaques found in the brains of Alzheimer patients. The peptides result from the amyloid precursor protein (APP), which is cut by certain enzymes to yield Aβ. Aβ molecules can aggregate to form oligomers (known as "seeds") which are believed to be able to induce other Aβ molecules to also take the misfolded oligomeric form, leading to a chain reaction akin to a prion infection. The seeds or the resulting amyloid plaques are toxic to nerve cells. The other protein implicated in Alzheimer's disease, tau protein, also forms such prion-like misfolded oligomers, and there is some evidence that misfolded Aβ can induce tau to misfold.
25μg
Antibody Type: Recombinant
Host Species: Rabbit
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: IHC-P - Quality tested IHC-F, Direct ELISA, WB - Verified
Recommended Usage: Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 2.5 - 10 µg/mL is suggested. For immunohistochemistry, a concentration range of 5.0 - 10 µg/mL is suggested. Recommended usage concentration for direct ELISA application is 29 ng/mL. For western blotting, the suggested use of this reagent is 0.5 - 1.0 µg/mL. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: This antibody is not recommended for WB application. It specifically recognizes β-amyloid peptide 1-38 but has poor sensitivity against the target.
RRID: AB_2890865 (BioLegend Cat. No. 943301) AB_2890865 (BioLegend Cat. No. 943302)
Structure: Aβ 1-38 is 38 amino acid peptide with an expected molecular weight of 4 kD.
Distribution: Extracellular
Function: Apoptosis, Cell Adhesion, Endocytosis, Notch Signaling
Molecular Family: APP/β-Amyloid
Antigen References: 1. Watts J, et al. 2014. Proc Natl Acad Sci U S A. 111:10323-10328. 2. Condello C, et al. 2018. Proc Natl Sci U S A. 115:E782. 3. Chen G, et al. 2017. Acta Phamacologica Sinica. 38:1205-1235.
Gene ID: 351
UniProt: View information about beta-Amyloid 1-38 on UniProt.org
Clone: QA19A28
Regulatory Status: RUO
Other Names: APP, Amyloid Beta (A4) Precursor Protein, AD1, CVAP, Peptidase Nexin-II, Alzheimer Disease Amyloid Protein, Cerebral Vascular Amyloid Peptide, Protease Nexin-II, ABPP, APP-I, PN-II, AAA
Isotype: Rabbit IgG