Cobetter, BMS400T41H1K, Lifecube™ MS Single-use Mixing Bag Sterile by Gamma Irradiation

Check this product with a package size of 400 L / Top: an inlet + a 4" powder port. Side: a sampling port. Bottom: a drain/outlet. / None on Iright. Cobetter Lifecube Single-use Mixing Bags offer no-clean, many specifications, pre-sterilization, easy to install and flexibility of use, etc. The Lifecube Single-use Mixing bags are made of multi-layer co-extrusion film, feature good physical and chemical properties and extremely low gas permeability. Lifecube Single-use Mixing bags are suitable for a wide range of mixing steps in upstream and downstream processes.
Specifications

Materials
Mixing Type
Cobetter Lifecube MS Single-use Mixing Bags
Material
Cobetter Topene RB Film
Impeller
(MS)
Materials of Construction
Main part/ Welding pad: HDPE

Volume
50L - 3000L
Total Fluid Contact Area
1316 cm²
Main Height*
4 cm
Speed**
≤ 750 rpm
Tubing and Port
Inlet
50/100/200 L: 150cm 3/8" ID x 5/8" OD Lifemeta™ STT Pt-cured Silicone tubing + ECS Female Quick Connector with plug;
400~3000 L: 150cm 1/2" ID x 3/4" OD Lifemeta™ STT Pt-cured Silicone tubing + ECM Female Quick Connector with plug.
Outlet
50/100/200 L: 150cm 3/8" ID x 5/8" OD Lifemeta™ STT Pt-cured Silicone tubing + ECS Male Quick Connector with plug;
400~1000 L: 150cm 1/2" ID x 3/4" OD Lifemeta™ STT Pt-cured Silicone tubing + ECM Male Quick Connector with plug;
1500~3000 L: 300cm 1/2" ID x 3/4" OD Lifemeta™ STT Pt-cured Silicone tubing + ECM Male Quick Connector with plug.
Sampling
20cm 1/4" ID x 7/16" OD Lifemeta™ STT Pt-cured Silicone tubing + Needlefree Swabable Valve
Powder Port
4" TC (including silicone gasket, blind cap and tri-clamp)
Sterility
Delivery Condition
Sterile
Sterilization Method
Gamma Irradiation
Package
Pack Size
1/pack
Note:
*Height from the welding plate to the top of the impeller; 
**For reference only. The mixing speed is different from bag specifications, stirring volumes, solutions and brand of mixers. Please confirm the mixing speed and efficiency according to the actual situation.
Features
Magnetic suction/magnetic suspension mixing, integrated/split system, compatible with other brands
Fast installation, well mixing run and easy setup
Double-layer packaging, sterilized by 25~45 kGy gamma irradiation
Many specifications, meeting a variety of preparation applications
Customized bag sizes, flexibly match different specification of containers
Customized Tubings, connectors and filters
Sensors can be customized to allow on-line monitoring during the process
Hardware with audit trail and automatic management functions available
Applications
Buffer and culture medium preparation
Semi-finished products preparation
Batch mixing
Quality Assurance
ISO 9001:2015 quality management system
ISO Class 4.8/ ISO 7/ ISO 8 cleanroom production
100% leak testing
ADCF raw materials, complies with FDA 21 CFR Part 177-182 (Indirect food addictives)
Meet the requirement of current USP <87> Class VI, Biological Reactivity Test, In Vitro
Meet the criteria of the current USP <88> Class VI, Biological Reactivity Test In Vitro
Aqueous extraction contains < 0.25 EU/mL as determined by Limulus Amebocyte Lysate (LAL), USP <85>
Particulate matter in the product eluent meets the requirements in USP <788> for large volume parenterals
Verify gamma irradiation dose according to ISO 11137
Configuration Options
*Contact us for other configuration options. Q: What are the applicable conditions for the use of mixing bags?
1. Liquid-liquid mixing, solid-liquid mixing, such as media preparation, buffer preparation, intermediate product preparation, mixing of liquid collections from different batches, and so on.
2. The recommended temperature range is usually 0-40°C, pH range is 2.5-11.
3. Common specifications for mixing bags are 50L, 100L, 200L, 500L, 1000L, 1500L, 2000L, with a minimum nominal stirring volume of 20%.
Q: What is the minimum volume specification for the mixing bag?
Currently, we can provide mixing bags in a 20L specification, and the minimum mixing volume can be achieved at 4L. We also offer matching hardware systems (MG series).
All MP bags have the same specifications for the impeller.
The MG impellers come in three sizes: 100/50/20.
The MK impellers are available in different sizes for volumes below 100, 100-200, and 500-1000.
Q: Will a single-use system that has been irradiated have any impact on the product? Can irradiation residues be detected in the irradiated items?
No. The irradiation dose is validated to ensure sterilization effectiveness. Moreover, the irradiation process only involves energy absorption and does not involve direct contact with the radiation source. Therefore, there are no issues of irradiation residues in the disposable system.
Q: What is the minimum mixing volume for mixing bags?
Generally, the minimum mixing volume for mixing bags is 20% of the nominal volume of the bag, assuming complete mixing. However, if the aim is to achieve mixing effects, then a liquid level that reaches the height of the paddle blades is generally sufficient.
Q: What is the maximum mixing volume for mixing bags?
Typically, the maximum filling volume for mixing bags is 110% of the nominal volume. However, due to gas entering during the liquid filling process, the actual volume may be slightly smaller. If the liquid level is close to the maximum filling volume, it is recommended to add a vent filter.
Q: What is the installation process for single-use storage bags and mixing bags?
When customers receive the bags, they need to remove the two layers of outer packaging. The films are attached together.
First, position the bag right and stretch the drainage tube out of the drainage hole of the container. If there is a mixing paddle, align it with the magnetic head position, adjust the bag.
Then fill the liquid while adjusting the position and angle of the bag to fit the container. If it is a square container, the weld position of the bag is different, so it is necessary to confirm the top and bottom first, and then operate. If it is a round container, it is necessary to adjust the bag to ensure that it is vertically placed and the bag body is in contact with the wall of the drum.
All adjustments must be made as quickly as possible during the liquid filling process. After the liquid filling is completed, the bag is too heavy to adjust (do not pull the film, tube, etc.). If the final fit is poor, If the final fit is poor, it increases the risk of damage. (Paper instructions are included with the shipment.)
Q: What is the difference between magnetic stirring and magnetic levitation stirring?
Magnetic stirring: MP/MG series, with sufficient power and strong shear force, good mixing effect, and a rotation speed of usually ≤250rpm; Magnetic levitation stirring: ML/MK/MKP/MS series, with gentle stirring, low shear force, a rotation speed of 250rpm-1000rpm, zero friction, but high cost. There is no absolute good or bad, and the choice should be made based on the application.
Q: Can single-use products be irradiated again after expiration?
No, the validation test of single-use products is based on one-time irradiation, and the strength of the material and risks such as E&L have not been systematically validated for multiple irradiations.