CST, 10127S, DOCK2 Antibody

Polyclonal Antibody for studying DOCK2. Validated for Western Blotting,Immunoprecipitation. Highly specific and rigorously validated in-house, DOCK2 Antibody (CST #10127) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:100 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody . Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity DOCK2 Antibody recognizes endogenous levels of total DOCK2 protein. Species Reactivity: Human Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human DOCK2 protein. Antibodies are purified by protein A and peptide affinity chromatography. Background DOCK2 (dedicator of cytokinesis 2) is a member of the DOCK-A subfamily of guanine nucleotide exchange factors (GEFs) which function as activators of small G proteins (1,3). Expressed in leukocytes, DOCK2 activates isoforms of Rac which regulate chemotaxis as part of the immune response (1,2,4). Alternate Names dedicator of cyto-kinesis 2; dedicator of cytokinesis 2; Dedicator of cytokinesis protein 2; DOCK2; FLJ46592; IMD40; KIAA0209 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 200 SOURCE: Rabbit