CST, 11830S, SSTR1 Antibody

Polyclonal Antibody for studying SSTR1. Validated for Western Blotting. Highly specific and rigorously validated in-house, SSTR1 Antibody (CST #11830) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity SSTR1 Antibody recognizes endogenous levels of total SSTR1 protein. Species Reactivity: Rat Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val365 of human SSTR1 protein. Antibodies are purified by protein A and peptide affinity chromatography. Background Somatostatin receptors are part of the super family of G protein-coupled receptors. Five genes encoding six different somatostatin receptor subtypes (SSTR1, SSTR2A, SSTR2B, SSTR3, SSTR4, and SSTR5) have been cloned (1). Somatostatin receptors are activated by somatostatin, a neuropeptide that acts as a neurotransmitter in the brain that regulates hormone secretion from endocrine tissues (2). Somatostatin receptors are found to be highly expressed on human neuroendocrine tumors (3). mRNA expression data and immunohistochemical studies indicate high expression of SSTR1 in pituitary and gastroenteropancreatic tumor, renal, colorectal and breast cancer, meningioma, glioma neuroblastoma, and pheochromocytoma (3). Alternate Names somatostatin receptor 1; Somatostatin receptor type 1; SRIF-2; SS-1-R; SS1-R; SS1R; SSR1; SSTR1 Specification REACTIVITY: R SENSITIVITY: Endogenous MW (kDa): 40, 80 SOURCE: Rabbit