CST, 12479S, PANK2 (D11E2) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying PANK2 mouse. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, PANK2 (D11E2) Rabbit Monoclonal Antibody (CST #12479) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity PANK2 (D11E2) Rabbit Monoclonal Antibody recognizes endogenous levels of total PANK2 protein. Species Reactivity: Mouse Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu76 of mouse PANK2 protein. Background Pantothenate kinase 2 (PANK2) catalyzes the first step in coenzyme A (CoA) biosynthesis (1,2). Human PANK2 protein is located in the mitochondria, and research studies have shown some mutations in human are linked to neurodegeneration (2). Alternatively, mouse PANK2 protein localizes in the cytosol, and defective PANK2 protein in mice leads to retinal degeneration (1,3). Alternate Names 4933409I19Rik; AI642621; MGC118448; OTTMUSP00000017161; Pank2; Pantothenate kinase 2; pantothenate kinase 2 (Hallervorden-Spatz syndrome); Pantothenate kinase 2, mitochondrial Specification REACTIVITY: M SENSITIVITY: Endogenous MW (kDa): 49 Source/Isotype: Rabbit IgG