CST, 12524T, CBARA1/MICU1 (D4P8Q) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying MICU1. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, CBARA1/MICU1 (D4P8Q) Rabbit Monoclonal Antibody (CST #12524) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity CBARA1/MICU1 (D4P8Q) Rabbit Monoclonal Antibody recognizes endogenous levels of total CBARA1/MICU1 protein. Species Reactivity: Human, Mouse, Rat, Monkey Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys110 of human CBARA1/MICU1 protein. Background CBARA1/MICU1 is a mitochondrial protein associated to the mitochondrial inner membrane that is comprised of two EF hand helix-loop-helix motifs. CBARA1/MICU1 is involved in mitochondrial calcium entry, metabolic coupling between cytosolic calcium transients, and activation of matrix dehydrogenases (1). Mitochondrial CBARA1/MICU1 is required to preserve normal mitochondrial calcium concentration below the equilibrium level by interacting with the uniporter pore-forming subunit MCU (2). CBARA1/MICU1 is important in pancreatic β-cell mitochondrial calcium uptake and sustained insulin secretion (3). Alternate Names ara CALC; atopy related autoantigen; Atopy-related autoantigen CALC; CALC; calcium binding atopy-related autoantigen 1; Calcium uptake protein 1, mitochondrial; Calcium-binding atopy-related autoantigen 1; CBAA1; CBARA1; DKFZp564C246; EFHA3; FLJ12684; MICU1; mitochondrial calcium uptake 1; MPXPS Specification REACTIVITY: H M R Mk SENSITIVITY: Endogenous MW (kDa): 47 Source/Isotype: Rabbit IgG