CST, 13057T, DAZL (D2A4) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying DAZL. Validated for Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, DAZL (D2A4) Rabbit Monoclonal Antibody (CST #13057) is ready to ship. Product Usage Information Immunohistochemistry (Paraffin): 1:100 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Immunohistochemistry (Paraffin) Specificity / Sensitivity DAZL (D2A4) Rabbit Monoclonal Antibody recognizes endogenous levels of total DAZL protein. Species Reactivity: Human, Mouse Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human protein. Background The human (Deleted in Azoospermia) gene family contains at least three members that encode RNA-binding proteins with a common RNA-recognition motif (1). An autosomal homolog of DAZ, DAZL (DAZ-like), is specifically expressed in germ cells and is essential for the Specification of the germ cell lineage during embryogenesis and during gametogenesis in adults of both sexes (2,3). DAZL may function by directly recruiting poly(A)-binding proteins (PABPs) in order to activate silent mRNAs during germ cell development (2). Deletions encompassing the Y chromosomal genes are the most common molecularly defined cause of infertility in humans (4,5). Alternate Names DAZ homolog; DAZ-like autosomal; DAZH; DAZL; DAZL1; DAZLA; deleted in azoospermia like; Deleted in azoospermia-like; Deleted in azoospermia-like 1; deleted in azoospermia-like autosomal; germline specific RNA binding protein; MGC26406; spermatogenesis gene on the Y-like autosomal; SPGY-like-autosomal; SPGYLA; testis secretory sperm-binding protein Li 204a Specification REACTIVITY: H M SENSITIVITY: Endogenous MW (kDa): 38 Source/Isotype: Rabbit IgG