CST, 13119S, LSm2 (D9X6C) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying LSm2. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, LSm2 (D9X6C) Rabbit Monoclonal Antibody (CST #13119) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity LSm2 (D9X6C) Rabbit Monoclonal Antibody recognizes endogenous levels of total LSm2 protein. Species Reactivity: Human, Mouse, Rat, Monkey Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly64 of human LSm2 protein. Background LSm proteins are members of an ancient family of RNA binding proteins that function in RNA metabolism (1,2). Two LSm complexes or rings have been identified based on protein composition: LSm1-7 and LSm2-8 (1). The cytoplasmic LSm1-7 complex is involved in mRNA degradation (3) while the LSm2-8 ring is required for pre-tRNA and rRNA maturation (4,5) and regulation of pre-mRNA splicing through its association with U6 snRNA (6). Recent studies show that LSm2-8 complex functions in the biogenesis of telomerase RNA (1). Alternate Names C6orf28; G7B; LSM2; LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated; LSM2 homolog, U6 small nuclear RNA associated; LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae); LSM2 U6 small nuclear RNA and mRNA degradation associated; Protein G7b; Small nuclear ribonuclear protein D homolog; snRNP; snRNP core Sm-like protein Sm-x5; U6 snRNA-associated Sm-like protein LSm2; YBL026W Specification REACTIVITY: H M R Mk SENSITIVITY: Endogenous MW (kDa): 11 Source/Isotype: Rabbit IgG