CST, 13125C, PathScan® Phospho-HER4/ErbB4 (panTyr) Sandwich ELISA Kit

ELISA Kit for studying HER4/ErbB4 (Pan Tyr) phosphate in the research area. Protocol Available protocols: ELISA+ Specificity / Sensitivity PathScan Species Reactivity: Human Background Research studies have implicated the HER/ErbB receptor tyrosine kinase family in normal development, cardiac function and cancer (1,2). HER4/ErbB4, like other family members, has four ectodomains, a single transmembrane domain and a cytoplasmic tail containing the active tyrosine kinase domain (3). By binding to neuregulins and/or EGF family ligands, ErbB4 forms either a homodimer or heterodimer with other ErbB family members, which results in receptor activation and signaling (3). ErbB4 is ubiquitously expressed with the highest expression occurring in brain and heart. The expression of ErbB4 in breast cancer, pediatric brain cancer and other types of carcinomas has been reported in research studies suggesting that ErbB4 expression is involved in both normal tissue development and carcinogenesis (3). Alternate Names 4ICD; ALS19; avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4; E4ICD; erb-b2 receptor tyrosine kinase 4; ERBB4; ERBB4 intracellular domain; HER4; human epidermal growth factor receptor 4; MGC138404; p180erbB4; Proto-oncogene-like protein c-ErbB-4; Receptor tyrosine-protein kinase erbB-4; s80HER4; Tyrosine kinase-type cell surface receptor HER4; v-erb-a erythroblastic leukemia viral oncogene homolog 4; v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian); v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4 Specification REACTIVITY: H